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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Antibiotic Resistance in Uropathogenic E. Coli Strains Isolated from Non-Hospitalized Patients in Pakistan
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Antibiotic Resistance in Uropathogenic E. Coli Strains Isolated from Non-Hospitalized Patients in Pakistan

机译：从巴基斯坦非住院患者中分离出的致病性大肠杆菌菌株的抗生素耐药性

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Purpose: To study multidrug-resistance in Uropathogenic E. Coli (UPEC) isolated from non-hospitalized patients.Materials and Methods:Altogether, 250 bacterial samples were collected from non-hospitalized patients. Their identifications were done on basis of Gram-staining, colony morphology, biochemical testing and PCR. Susceptibility testing was performed by using standard protocols which were recommended by CLSI. Statistical analysis: For comparisons, statistical analysis was performed by using software, Graphpad Prism 5.0. Results: In total, 32% (n = 80) of the isolates were identified as E. Coli strains and their susceptibility patterns for different antibiotics were determined. The data indicated least resistance against tazocin [(TZP) -1.25%], amikacin [(AK) -1.8%], tigecycline [(TGC)- 2.5%] and nitrofurantoin [(F) -3.75%]. For both minocycline (MH) and sulzone (SUL), resistance rate was 5%, for gentamicin (CN), it was 16.25%, while higher resistances were observed against cephalothine [(KF)- 70%], cefotaxime [(CTX) -58.5%], ceftazidime [(CAZ)- 57.5%], cefepime [(FEP) -55%], cefuroxime and cefixime [(CXM) (CFM)- 53.75 %]. Resistance against ciprofloxacin (CIP) was 57.5%, for norfloxacine (NOR), it was 52.5% and incase of sparfloxacin (SPX), it remained 55%. High percentage of the isolates were resistant to cotrimoxazole [(SXT) -86%] and Amoxicillin [AMX-CLA (AMC)- 76%]. No resistance against meropenem (MEM) was observed. Conclusion: Highest level of drug-resistance was observed against trimethoprim-sulfamethoxazole (TMP-SMZ) among clinical isolates of uropathogenic E. Coli collected from non-hospitalized patients.
机译：目的：研究从非住院患者中分离出的Uropathogenic E. Coli（UPEC）的多药耐药性。材料与方法：总共从非住院患者中收集了250份细菌样品。他们的鉴定是根据革兰氏染色，菌落形态，生化检测和PCR进行的。使用CLSI推荐的标准协议进行敏感性测试。统计分析：为了进行比较，使用软件Graphpad Prism 5.0进行统计分析。结果：总共鉴定出32％（n = 80）的分离株为大肠杆菌菌株，并确定了它们对不同抗生素的敏感性模式。数据表明对他唑星[（TZP）-1.25％]，丁胺卡那霉素[（AK）-1.8％]，替加环素[（TGC）-2.5％]和​​呋喃妥因[[F] -3.75％]的抵抗力最小。对于米诺环素（MH）和sulzone（SUL），耐药率均为5％，对于庆大霉素（CN）的耐药率则为16.25％，而观察到的头孢噻嗪[（KF）-70％]，头孢噻肟[（CTX）]的耐药率更高。 -58.5％]，头孢他啶[（CAZ）-57.5％]，头孢吡肟[（FEP）-55％]，头孢呋辛和头孢克肟[（CXM）（CFM）-53.75％]。环丙沙星（CIP）的耐药率为57.5％，诺氟沙星（NOR）的耐药率为52.5％，司帕沙星（SPX）的耐药率为55％。高百分比的分离株对考特莫唑[（SXT）-86％]和阿莫西林[AMX-CLA（AMC）-76％]耐药。没有观察到对美洛培南（MEM）的抗性。结论：从非住院患者收集的尿路致病性大肠杆菌临床分离株中，对甲氧苄啶-磺胺甲基异恶唑（TMP-SMZ）观察到最高的耐药性。

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