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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Hepatoprotective Role of Caesalpenia bonduc: A Histopathological and Biochemical Study
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Hepatoprotective Role of Caesalpenia bonduc: A Histopathological and Biochemical Study

机译：Caesalpenia bonduc的保肝作用：组织病理学和生化研究

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Background: Hepatotoxicity is one of the inevitable side effects of long term use of medicines in many different disorders, chronic use of alcohol and in certain infectious disorders. Even though there are few effective drugs to treat such hepatotoxicity, mortality due to hepatotoxicity is increasing day by day. Therefore, in search of alternative and more effective medicine we found that Caesalpenia bonduc (CB), a shrub grows in hotter places of south Asia has been effectively used to treat such hepatotoxicity in folk medicine.Aim: Aim of the study is to scientifically evaluate the hepatoprotective nature of aqueous extract of CB using Carbon tetrachloride(CCl4) induced hepatotoxic rat model.Materials and Methods and Result: Elevated levels of blood ALT, AST and ALT enzymes were found in CCl4 induced hepatotoxic rat models. Treating these animals with CB either prior or after the induction of hepatotoxicity, shows significant decrease in the levels of ALP, AST, and ALT in their blood in comparison with the untreated hepatotoxic group. Additionally, histologically, hepatotoxic rats show necrotic changes & vacuolation in their hepatocytes, altered hepatic architecture and congested hepatic sinusoids. However, such histopathological adverse changes were minimized when these animals treated with CB.Conclusion: Results of the present study indicate that CB acts as both preventive and curative hepatoprotector.
机译：背景：肝毒性是在许多不同疾病，长期饮酒和某些传染性疾病中长期使用药物的不可避免的副作用之一。即使很少有有效的药物可以治疗这种肝毒性，但是由于肝毒性而导致的死亡率正在逐日增加。因此，在寻找替代的更有效的药物时，我们发现在南亚较热的地方生长的灌木凯撒（Caesalpenia bonduc，CB）已被有效地用于治疗民间医学中的这种肝毒性。目的：该研究的目的是科学评估材料，方法和结果：在CCl4诱导的肝毒性大鼠模型中发现血液ALT，AST和ALT酶水平升高。与未治疗的肝毒性组相比，在诱导肝毒性之前或之后用CB治疗这些动物显示其血液中ALP，AST和ALT的水平明显降低。另外，在组织学上，肝毒性大鼠肝细胞显示坏死改变和空泡化，肝结构改变，肝正弦曲线充血。然而，当这些动物用CB治疗时，这种组织病理学不良变化减至最小。结论：本研究结果表明CB既是预防性的也是治疗性的保肝剂。

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