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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Nevirapine: Most Common Cause of Cutaneous Adverse Drug Reactions in an Outpatient Department of a Tertiary Care Hospital
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Nevirapine: Most Common Cause of Cutaneous Adverse Drug Reactions in an Outpatient Department of a Tertiary Care Hospital

机译：奈韦拉平：三级医院门诊部皮肤药物不良反应的最常见原因

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Introduction: Skin is the most commonly involved organ in adverse drug reactions. Most of the cutaneous adverse drug reactions (CADRs) being of mild to moderate severity are likely to be diagnosed and treated in an outpatient setting. Consequently, knowledge regarding morphological pattern, severity and drugs implicated in causation of these CADRs has important implications for healthcare personnel. Aim: To determine the current clinical pattern of CADRs and to assess their causality and severity with the help of standard scales. Study design and setting: A prospective, observational study was conducted in the outpatient department of skin and venereal disease in a tertiary care hospital. Materials and Methods: Patients with suspected CADR after consumption of systemic drug(s) were enrolled in the study. Data regarding demographics, clinical manifestations of CADR, drug history preceding the reaction, concomitant illness, relevant laboratory investigations etc was obtained. This data was then analysed for morphological pattern, causality and severity. CADRs with causality assessment possible and above on the basis of World Health Organization-Uppsala Monitoring Centre causality assessment system were considered for analysis. S tatistics: Descriptive statistics were used to express results of pattern, severity and causality of CADRs. Results: Ninety patients were enrolled in the study. Male to female ratio for CADRs was 1:2.33. Maculopapular rash was most commonly encountered CADR in 76.67% cases followed by urticaria (8.89%), Stevens-Johnson syndrome (4.4%) and fixed dose eruptions (3.33%). Antiretrovirals were implicated in 75.56% (68/90) of CADRs. Nevirapine was suspected in 52 out of 90 (57.77%) cases of CADRs which included 39 cases of maculopapular rash, five cases of urticaria, four cases of Stevens-Johnson syndrome, and two cases each of pustular rash and angioedema respectively. Antimicrobials, antiepileptics and Non-steroidal Anti-inflammatory Drugs (NSAIDs) were other suspected drugs. Conclusion: Antiretrovirals especially nevirapine was implicated in variety of CADRs ranging from maculopapular rash to life-threatening reactions like Stevens-Johnson syndrome in an outpatient setting. Women were twice as susceptible as men for CADRs.
机译：简介：皮肤是药物不良反应中最常见的器官。轻度至中度的大多数皮肤不良药物反应（CADR）可能在门诊患者中得到诊断和治疗。因此，有关这些CADR的因果关系的形态，严重性和药物方面的知识对医护人员具有重要意义。目的：确定CADR的当前临床模式，并借助标准量表评估其因果关系和严重程度。研究设计和设置：前瞻性观察性研究是在三级医院的皮肤和性病门诊进行的。材料和方法：服用全身性药物后疑似CADR的患者入选本研究。获得了有关人口统计学，CADR的临床表现，反应之前的药物史，合并症，相关实验室检查等方面的数据。然后分析此数据的形态，因果关系和严重程度。考虑使用基于世界卫生组织-乌普萨拉监测中心因果关系评估系统进行可能因果关系评估的CADR进行分析。统计：描述性统计用于表达CADR的模式，严重性和因果关系的结果。结果：90名患者被纳入研究。 CADR的男女比例为1：2.33。在76.67％的病例中，最常见的是斑丘疹性CADR，其次是荨麻疹（8.89％），史蒂文斯-约翰逊综合症（4.4％）和固定剂量爆发（3.33％）。抗逆转录病毒药物涉及75.56％（68/90）的CADR。在90例CADR病例中，有52例（57.77％）怀疑含有奈韦拉平，其中包括39例斑丘疹，5例荨麻疹，4例史蒂文斯-约翰逊综合症和2例脓疱疹和血管性水肿。抗生素，抗癫痫药和非甾体类抗炎药（NSAIDs）是其他可疑药物。结论：在门诊患者中，抗逆转录病毒药物尤其是奈韦拉平与多种CADR有关，从斑丘疹到威胁生命的反应，如史蒂文斯-约翰逊综合症。对于CADR，女性的易感性是男性的两倍。

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