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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Comparative Study on Clinical and Biochemical Parameters in Amlodipine and Cilnidipine Treated Hypertensive Patients FC01-FC05
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A Comparative Study on Clinical and Biochemical Parameters in Amlodipine and Cilnidipine Treated Hypertensive Patients FC01-FC05

机译：氨氯地平和西尼地平治疗的高血压患者FC01-FC05的临床和生化指标的比较研究

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Introduction: Hypertension is a major health issue worldwide. Calcium Channel Blockers (CCBs) are the most commonly used antihypertensive agents. CCBs act on voltage-dependent calcium channels and they were categorized into two subclasses, Dihydropyridine (DHP) and non-Dihydropyridine (non-DHP) derivative. Amlodipine is a third generation L-type of DHP and Cilnidipine is a novel L/N-type of DHP CCB, both drugs have excellent pharmacological profiles with the unique actions.Aim: To study the clinical and biochemical profile in Amlodipine and Cilnidipine treated mild to moderate hypertensive patients.Materials and Methods: The present study was a cross-sectional study. A total of 140 mild to moderate hypertensive patients (HTN classified according to Joint National Committee-8 (JNC-8) HTN guideline), 70 were in Amlodipine group (Group-A), and other 70 patients were in Cilnidipine group (Group-B). Group-A receiving Tab Amlodac 5 mg/day and Group-B receiving Tab Cilacar 10 mg/day, and both the group receiving respective medications since more than six months. Patients enrolled into the study with due consideration of eligibility criteria. Demographic, clinical and biochemical parameters were noted and compared.Results: Demographic parameters are matched, there was no significant difference seen between two study groups. Systolic and Diastolic Blood Pressure (SBP and DBP) showed a significant difference (p<0.001). There was no significant difference in pulse rate between the two groups, both QT/QTc showed statistically significant difference (p<0.001). The biochemical parameters like serum creatinine, albumin, globulin, total protein, serum Na+, fractional excretion of Na+, serum osmolality, vanillyl mandelic acid, were compared between two study groups, there was no significant difference seen between the two groups.Conclusion: The Amlodipine and Cilnidipine both are equally effective antihypertensive drugs. Cilnidipine treated group showed more reduction in blood pressure than the Amlodipine treated group and there was no significant change in heart rate between the two groups. Cilnidipine group showed comparatively shortened QT/QTc interval than the Amlodipine group.
机译：简介：高血压是全球主要的健康问题。钙通道阻滞剂（CCB）是最常用的降压药。 CCB作用于电压依赖性钙通道，它们被分为两个亚类：二氢吡啶（DHP）和非二氢吡啶（non-DHP）衍生物。氨氯地平是DHP的第三代L型，西尼地平是DHP CCB的新型L / N型，两种药物均具有优异的药理作用和独特的作用。目的：研究氨氯地平和西尼地平治疗轻症的临床和生化特征中度高血压患者。材料与方法：本研究为横断面研究。总共140例轻至中度高血压患者（HTN根据联合全国委员会8（JNC-8）HTN指南分类），其中70例属于氨氯地平组（A组），另外70例属于Cilnidipine组（ B）。 A组接受Tab Amlodac 5 mg /天，B组接受Tab Cilacar 10 mg /天，并且两个组都已接受六个月以上的药物治疗。参加研究的患者应适当考虑入选标准。结果：人口统计学参数匹配，两个研究组之间没有显着差异。收缩压和舒张压（SBP和DBP）显示出显着差异（p <0.001）。两组之间的脉搏率无显着差异，QT / QTc均显示出统计学上的显着差异（p <0.001）。在两个研究组之间比较了血清肌酐，白蛋白，球蛋白，总蛋白，血清Na +，Na +的排泄分数，血清渗透压，香草基扁桃酸等生化参数，两组之间无显着差异。氨氯地平和西尼地平都是同等有效的降压药。西尼地平治疗组的血压下降幅度比氨氯地平治疗组大，两组之间的心率无明显变化。与氨氯地平组相比，西尼地平组的QT / QTc间隔相对缩短。

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