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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effect of 12-week High Intensity Interval Training Program on C-Reactive Protein and Insulin Resistance in Women with Polycystic Ovary Syndrome
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Effect of 12-week High Intensity Interval Training Program on C-Reactive Protein and Insulin Resistance in Women with Polycystic Ovary Syndrome

机译：12周高强度间歇训练计划对多囊卵巢综合征女性的C反应蛋白和胰岛素抵抗的影响

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Polycystic ovary syndrome (PCOS) is associated with metabolic derangements including insulin resistance which causes dyslipidemia and glucose intolerance. In addition, low-grade inflammation reflected by elevated serum High-sensitivity C-Reactive Protein (hs-CRP) levels is common in PCOS patients. Non-pharmacological interventions such as exercise training can play an important role in reducing insulin resistance and inflammatory markers.Aim: To determine the effect of 12-weeks of High Intensity Interval Training (HIIT) program on insulin resistance and hs-CRP in women with PCOS.Materials and Methods: In this Quasi-experimental study, 24 female patients with PCOS were included and divided into two groups {HIIT (12 cases) and control group (12 cases)}. HIIT consisted of three sessions for 12-weeks of intense anaerobic exercise with short periods (4 minutes) to reach 90% of maximal heart rate for 2 sessions and 1 session with moderate exercise to reach 70% of maximal heart rate. The control group resumed normal daily life without any intervention. Serum hs-CRP and fasting glucose and insulin levels were measured at baseline and after 12-weeks and HOMA-IR was calculated. Paired t-test was used to compare the measured continuous variables.Results: Mean (±SD) HOMA-IR in HIIT group decreased from 3.22 (±1.72) to 1.99 (±0.66); p=0.001. Mean (±SD) serum hs-CRP level in HIIT group decreased from 6.3 (±1.41) to 4.7 (±1.25) mg/L; p=0.033. No significant decrease was seen in control group.Conclusion: HIIT is associated with improvement of insulin resistance and decrease in hs-CRP in PCOS patients. This exercise training can be used as early intervention in PCOS patients.
机译：多囊卵巢综合征（PCOS）与包括胰岛素抵抗在内的代谢异常有关，胰岛素异常导致血脂异常和葡萄糖耐受不良。此外，PCOS患者常见血清高敏C反应蛋白（hs-CRP）水平升高所反映的轻度炎症。非药物干预措施，例如运动训练，在降低胰岛素抵抗和炎症标志物方面可以发挥重要作用。目标：确定12周高强度间歇训练（HIIT）计划对胰岛素抵抗和hs-CRP的影响材料与方法：在这项准实验研究中，纳入了24例女性PCOS患者，分为两组{HIIT（12例）和对照组（12例）}。 HIIT包括三个疗程，分别进行为期12周的短时间（4分钟）的剧烈无氧运动，以达到2个疗程的最大心率的90％，以及1个疗程，进行中等强度的无氧运动，以达到最大心率的70％。对照组无需任何干预即可恢复正常的日常生活。在基线和12周后测量血清hs-CRP和空腹葡萄糖和胰岛素水平，并计算HOMA-IR。结果：HIIT组的平均（±SD）HOMA-IR从3.22（±1.72）降低至1.99（±0.66）;结果： p ＝ 0.001。 HIIT组的血清hs-CRP平均（±SD）从6.3（±1.41）降至4.7（±1.25）mg / L; p ＝ 0.033。对照组未见明显降低。结论：HIIT与PCOS患者的胰岛素抵抗改善和hs-CRP降低有关。该运动训练可用作PCOS患者的早期干预。

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