...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Outbreak of Dengue Fever in Bundelkhand Region: A Tertiary Care Hospital Study Report
【24h】

Outbreak of Dengue Fever in Bundelkhand Region: A Tertiary Care Hospital Study Report

机译：Bundelkhand地区的登革热疫情：三级医院研究报告

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dengue is most widely spread mosquito-borne viral disease which is a major public health threat globally. The incidence of dengue fever is increasing year after year with morbidity and mortality in urban and suburban areas of tropical and subtropical regions of the world. However, data related to its exact incidence in many parts of India is still lacking. The present study reports the dengue fever outbreak in 2018 in Bundelkhand region.Aim: To know the incidence of laboratory-confirmed dengue cases among clinically suspected patients in Bundelkhand region and to examine the diagnostic efficacy of two commercially available dengue NS1 and IgM ELISA tests.Materials and Methods: A total of 1794 blood samples of suspected dengue patients over the year 2018 (January to December) from Medical College and nearby hospitals of Bundelkhand region sent to Microbiology department for routine dengue diagnosis were included in this study. For the laboratory diagnosis of dengue cases, NS1 and IgM ELISA tests were performed by using the commercially available ?RecombiLISA Dengue Ag ELISA kit (CTK Biotech, Inc., San Diego, CA)? and ?National Institute of Virology (NIV) dengue IgM capture ELISA kit (NIV, Pune, India)? as per the manufacturer?s protocol respectively.Results: Out of 1794 suspected dengue cases, 1014 (56.52%) were males and 780 (43.47%) were females. Majority {1344 (74.9%)} of patients were adults with mean age of 29.2±12.8 years, while 25.1% were paediatric cases with mean age of 9.1±3.72 years. Out of 1794 cases, 625 (34.8%) patients were found to be dengue positive by NS1 and/or IgM dengue ELISA. In the present study, the first dengue ELISA positive case of 2018 was detected in the last week of June. The highest positivity rate was observed in October (42.3%), followed by November (38.9%). Maximum number of dengue cases were detected from Jhansi (38.8%), followed by Lalitpur (37.6%), Banda (26.3%) and Jalaun (20.2%), etc.Conclusion: The author?s experience of dengue fever outbreak in the year 2018 in Bundelkhand region has been demonstrated in this study. Both NS1 and IgM ELISA tests were useful for the laboratory confirmation of dengue cases. NS1 in combination with IgM ELISA offers most sensitive diagnosis for dengue as few cases which were missed by IgM were picked by NS1 ELISA test (and vice versa). Hence, continuous monitoring for dengue infection is important during the post-monsoon season when the peak of dengue virus infection was observed.
机译：登革热是最广泛传播的蚊媒病毒性疾病，是全球主要的公共卫生威胁。在世界热带和亚热带地区的城市和郊区，登革热的发病率与发病率和死亡率逐年增加。但是，仍然缺乏与其在印度许多地方的确切发病率有关的数据。本研究报告了2018年班德尔汉德地区的登革热暴发。目的：了解班德尔汉德地区临床疑似患者中实验室确诊的登革热病例的发生率，并检查两种市售登革热NS1和IgM的诊断功效ELISA测试。材料与方法：本研究包括2018年（1月至12月）从医学院和本德班德地区的附近医院送往微生物学部门进行常规登革热诊断的1794例疑似登革热患者血液样本。研究。为了对登革热病例进行实验室诊断，使用市售的“ RecombiLISA Dengue Ag ELISA试剂盒（CTK Biotech，Inc.，圣地亚哥，加利福尼亚）”进行了NS1和IgM ELISA测试。国家病毒学研究所（NIV）登革热IgM捕获ELISA试剂盒（NIV，印度浦那）？ 结果：在1794例疑似登革热病例中，男性为1014例（56.52％），女性为780例（43.47％）。多数{1344（74.9％）}患者为成人，平均年龄为29.2±12.8岁，而小儿科患者为25.1％，平均年龄为9.1±3.72岁。通过NS1和/或IgM登革热ELISA，在1794例病例中，发现625例（34.8％）登革热阳性。在本研究中，在6月的最后一周检测到2018年的第一例登革热ELISA阳性病例。十月的阳性率最高（42.3％），其次是十一月的阳性率（38.9％）。从詹西（38.8％），拉利特布尔（37.6％），班达（26.3％）和贾劳恩（20.2％）等发现登革热病例最多。结论：作者对登革热暴发的经历这项研究证明了Bundelkhand地区2018年的发展趋势。 NS1和IgM ELISA试验都可用于实验室确诊登革热病例。 NS1与IgM ELISA相结合可为登革热提供最灵敏的诊断，因为通过NS1 ELISA测试挑选出IgM遗漏的病例很少（反之亦然）。因此，在季风后季节观察到登革热病毒感染高峰时，连续监测登革热感染很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号