...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effects Of Atenolol And Nebivolol On Blood Pressure And On ECG In Patients Of Stage-1 Hypertension A Comparative Study
【24h】

Effects Of Atenolol And Nebivolol On Blood Pressure And On ECG In Patients Of Stage-1 Hypertension A Comparative Study

机译：阿替洛尔和奈必洛尔对一级高血压患者血压和心电图的影响比较研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background:?-blockers are used as first line antihypertensive drugs.Aim:To compare the effects of atenolol and nebivolol on blood pressure and ECG in patients of Stage 1 hypertension.Setting: This study was conducted by the departments of pharmacology and general medicine of a tertiary care teaching hospital in India.Study Design:Prospective single blind randomized trial over 6 months.Materials and Methods:Of the 102 patients randomized for the trial (atenolol n=50, nebivolol n=52), 26 patients were lost to follow-up. The 76 patients, who attended the three reviews at 3, 6 and 12 weeks following recruitment to the trial, were included for analysis. During each of the follow up visits, blood pressure and ECG were recorded. Corrected QT interval (QTc) was calculated using the Bazett's formula. The effect of each drug at 3, 6 and 12 weeks were compared with the baseline and were analysed using the paired ?￥t?| test, whilst the comparison between the two drugs (baseline, 3, 6 and 12 weeks) was performed using the unpaired ?￥t?|test.Results:Both the drugs significantly reduced (P<0.001) systolic and diastolic blood pressure during the follow-up visits. QTc was significantly reduced from baseline values at 3, 6 and 12 weeks of therapy with atenolol, but only at 6 weeks with nebivolol.Conclusion:Both atenolol and nebivolol appear to have similar antihypertensive effects in the short term. The effect of the anti-hypertensive agent on QTc appears to be more pronounced with atenolol than with nebivolol.
机译：背景：β-受体阻滞剂用作一线降压药。目的：比较阿替洛尔和奈比洛尔对1型高血压患者血压和心电图的影响。地点：本研究由美国药理学和普通医学部门进行研究设计：为期6个月的前瞻性单盲随机试验材料与方法：在102例随机分组的患者（阿替洛尔n = 50，奈比洛尔n = 52）中，有26名患者失去随访-向上。纳入研究的76名患者在入选该试验后的第3、6和12周参加了3次检查。在每次随访中，记录血压和心电图。使用Bazett公式计算校正后的QT间隔（QTc）。将每种药物在第3、6和12周的效果与基线进行比较，并使用配对的“ ￥ t”进行分析。结果，两种药物在未进行配对的“ ￥ t”测试中进行了比较（基线，第3、6和12周）。结果：两种药物均显着降低了（P <0.001）收缩压和舒张压。后续访问。阿替洛尔治疗3、6和12周时QTc较基线值显着降低，而奈必洛尔仅在6周时QTc降低。阿替洛尔比奈必洛尔对降压药的QTc影响更明显。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号