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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Inducible AmpC Beta-Lactamase Producing Pseudomonas Aeruginosa Isolated In A Rural HospitalOf Central India
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Inducible AmpC Beta-Lactamase Producing Pseudomonas Aeruginosa Isolated In A Rural HospitalOf Central India

机译：诱导型AmpCβ-内酰胺酶生产铜绿假单胞菌在印度中部农村医院分离

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Pseudomonas aeruginosa, one of the most common pathogen causing nosocomial infections, shows increasing resistance to β-lactam antibiotics especially by producing AmpC β-lactamase. Hence, this study was undertaken to determine the prevalence of inducible AmpC β-lactamases producing Pseudomonas aeruginosa in our hospital and their antibiotic susceptibility pattern to newer antipseudomonal antibiotics.Consecutive 244 Pseudomonas aeruginosa isolates were studied. Isolates showing blunting of ceftazidime zone of inhibition adjacent to cefoxitin disc were considered as screen positive and were selected for confirmation of inducible AmpC β-lactamases producing by modified three dimensional test and AmpC disc test. In vitro susceptibility pattern of antipseudomonal antibiotics were done by Kirby Bauer disc diffusion method.Out of 244 Pseudomonas aeruginosa isolates 47 (19.3%) were screen positive, which were confirmed by modified three dimensional test and AmpC disc test. The highest sensitivity pattern observed was Imipenem, Amikacin and Ciprofloxacin. We conclude that to avoid misuse of antibiotics and to start proper antibiotics to hospitalized patients, tests for AmpC β-lactamases should be done in Clinical Microbiology laboratories.
机译：铜绿假单胞菌（Pseudomonas aeruginosa）是引起医院感染的最常见病原体之一，显示出对β-内酰胺抗生素的耐药性增加，尤其是通过产生AmpCβ-内酰胺酶。因此，本研究旨在确定我院生产的可诱导性产AmpCβ-内酰胺酶的铜绿假单胞菌及其对新型抗假单胞菌抗生素的敏感性。连续研究244株铜绿假单胞菌。显示与头孢西丁盘相邻的抑制头孢他啶抑制区变钝的分离株被认为是筛查阳性，并通过改良的三维试验和AmpC盘试验选择用于确认可诱导的AmpCβ-内酰胺酶的产生。采用Kirby Bauer椎间盘扩散法进行抗假性抗生素的体外药敏试验，在244株铜绿假单胞菌中，筛选出47株（19.3％）呈阳性，经改良的三维试验和AmpC圆盘试验证实。观察到的最高灵敏度模式是亚胺培南，阿米卡星和环丙沙星。我们得出结论，为避免滥用抗生素并为住院患者使用适当的抗生素，应在临床微生物学实验室中进行AmpCβ-内酰胺酶测试。

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