Carbapenem hydrolyzing beta-lactamases in Pseudomonas aeruginosa

机译：碳青霉烯水解铜绿假单胞菌中的β-内酰胺酶

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Pseudomonas aerginosa causes seious infections especially in immuno-compromised host, through dissemination in hospitals. For. P. aeruginosa infections, carbapenms as well as piperacillin and third-generation cephems are potent beta-lactam antibiotics, but these beta-lactams are easily hydrolyzed by the carbapenemase produced by P. aeruginosa strains. The enzyme is a metallo-beta-lactamase with broad substrate spectrum, which extends to most beta-lactam antibiotics, except for monobactams. It was first identified in a P. aeruginosa strain and mediated by a plasmid pMS350 (1). Later, hospital infections caused by carbapenemase-producing P. aeruginosa have been reported (2).

机译：铜绿假单胞菌通过在医院中传播而引起严重的感染，尤其是在免疫受损的宿主中。对于。铜绿假单胞菌感染，碳青霉烯以及哌拉西林和第三代头孢是有效的β-内酰胺抗生素，但这些β-内酰胺很容易被铜绿假单胞菌菌株产生的碳青霉烯酶水解。该酶是具有广泛底物谱的金属-β-内酰胺酶，除单bactams外，其延伸至大多数β-内酰胺抗生素。它首先在铜绿假单胞菌菌株中鉴定，并由质粒pMS350介导（1）。后来，已经报道了由产生碳青霉烯酶的铜绿假单胞菌引起的医院感染（2）。

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《7th China-Japan International Congress of Microbiology Shanghai Symposium-2000 4-6 August 2000 Shanghai》|2000年|p.3-6|共4页
会议地点 Shanghai(CN);Shanghai(CN)
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Shizuko Iyobe;
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正文语种 eng
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入库时间 2022-08-26 14:28:51

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1. OXA-198, an acquired carbapenem-hydrolyzing class D beta-lactamase from Pseudomonas aeruginosa. [J] . El Garch F, Bogaerts P, Bebrone C, Antimicrobial agents and chemotherapy. . 2011,第10期

机译：OXA-198，一种从铜绿假单胞菌获得的水解碳青霉烯的D类β-内酰胺酶。
2. Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes. [J] . Poirel L, Lambert T, Turkoglu S, Antimicrobial agents and chemotherapy. . 2001,第2期

机译：铜绿假单胞菌的1类整合子的特征，其中包含bla（VIM-2）碳青霉烯水解β-内酰胺酶基因和两个新型氨基糖苷抗性基因盒。
3. Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes. [J] . Poirel L, Lambert T, Turkoglu S, Antimicrobial agents and chemotherapy. . 2001,第2期

机译：铜绿假单胞菌的1类整合子的特征，其中包含bla（VIM-2）碳青霉烯水解β-内酰胺酶基因和两个新型氨基糖苷抗性基因盒。
4. Carbapenem hydrolyzing beta-lactamases in Pseudomonas aeruginosa [C] . Shizuko Iyobe China-Japan international congress of microbiology . 2000

机译：Carbapenem水解β-内酰胺酶在假单胞菌铜绿假单胞菌
5. Characterization of Caudovirales Isolated from Freshwater Samples against Pseudomonas fluorescens and Host Range Testing against Pseudomonas aeruginosa [D] . ?Conrin, Mackenzie 2020

机译：有尾噬菌体目从对铜绿淡水样品中分离的荧光特性和寄主范围的测试，对绿脓杆菌
6. Properties of a novel carbenicillin-hydrolyzing beta-lactamase (CARB-4) specified by an IncP-2 plasmid from Pseudomonas aeruginosa. [O] . A M Philippon, G C Paul, A P Thabaut, 1986

机译：由铜绿假单胞菌的IncP-2质粒确定的新型羧苄青霉素水解β-内酰胺酶（CARB-4）的性质。
7. GES-18, a new Carbapenem-hydrolyzing GES-type beta-Lactamase from Pseudomonas aeruginosa that contains Ile80 and Ser170 residues [O] . Bebrone, C., Bogaerts, P., Delbrück, H., 2013

机译：GEs-18，一种来自铜绿假单胞菌的新型碳青霉烯水解GEs型β-内酰胺酶，含有Ile80和ser170残基

Carbapenem hydrolyzing beta-lactamases in Pseudomonas aeruginosa

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