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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Reactivation of the Cytomegalovirus(CMV) Infection in HIV Infected Patients
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The Reactivation of the Cytomegalovirus(CMV) Infection in HIV Infected Patients

机译：HIV感染患者的巨细胞病毒（CMV）感染的再激活

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Background: CMV is a virus of paradoxes and can be a potential killer or a silent companion lifelong. The CMV infection in immunocompromised patients carries high morbidity and mortality. In most people with a fully functional immune system, an initial infection with CMV may cause a mild flu like illness and later the virus remains dormant. A damaged immune system permits CMV reactivation. The magnitude of this problem in India has not been adequately investigated and it is still a major health problem, warranting strong preventive measures.Aims: We planned to study the prevalence of the CMV infection, re infection and the reactivation of the CMV infection in persons who were infected with HIV and AIDS and to correlate the reactivation of this disease with the CD 4 cell count in these patients.Settings And Design: This study was planned on patients who attended the ICTC center and it was conducted over a period of six months.Methods And Material: This study was conducted on 94 patients who were reactive for the HIV1 and/or HIV2 antibodies. The serum samples were tested for the IgG and IgM antibodies which were directed against CMV by ELISA.Results: Among the 94 cases, IgG antibodies were detected in 84 (89.4%) and IgM in 10(10.6%) cases. Among the 84 IgG cases, 42 were males and 42 were females. The IgM antibodies were positive in 4 (9.52%) out the 42 cases of AIDS and in 6 (11.5%) out of the 52 seropositive healthy individuals.Statistics: Percentage and Chi square tests were applied.Conclusion: As there is a high seroprevalence of the CMV infection in HIV positive patients and as there is a reactivation of CMV in healthy and immuno suppressed HIV positive patients, the early diagnosis of the CMV IgM antibodies help in the early detection of the reactivation of the virus before the development of the clinical manifestations. They improve the survival and protect the patients from the development of end organ disease.
机译：背景：CMV是一种自相矛盾的病毒，可以成为潜在的杀手或终身沉默的伴侣。免疫功能低下的患者的CMV感染具有较高的发病率和死亡率。在大多数具有完整免疫系统功能的人中，最初感染CMV可能会引起轻度流感，例如疾病，后来病毒仍处于休眠状态。免疫系统受损会导致CMV重新激活。在印度，这一问题的严重程度尚未得到充分调查，它仍然是一个主要的健康问题，需要采取强有力的预防措施。目的：我们计划研究人中CMV感染，再感染和CMV感染再激活的患病率谁感染了艾滋病毒和艾滋病，并将这种疾病的再激活与这些患者的CD 4细胞计数相关联。设置与设计：这项研究计划针对在ICTC中心就诊的患者进行，为期六个月方法和材料：本研究针对94名对HIV1和/或HIV2抗体有反应的患者进行。结果：在94例中，检测到84例（89.4％）的IgG抗体和10例（10.6％）的IgM抗体，检测血清中针对CMV的IgG和IgM抗体。在84例IgG病例中，男性42例，女性42例。 IgM抗体在42例AIDS中有4例（9.52％）阳性，在52例血清阳性健康个体中有6例（11.5％）阳性。 HIV阳性患者中CMV感染的发生以及健康和免疫抑制的HIV阳性患者中CMV的重新激活，CMV IgM抗体的早期诊断有助于在临床发展之前及早发现病毒的重新激活表现形式。它们提高了存活率，并保护患者免受终末器官疾病的发展。

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