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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Role of Magnesium Sulphate in Tuberculous Meningitis
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The Role of Magnesium Sulphate in Tuberculous Meningitis

机译：硫酸镁在结核性脑膜炎中的作用

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Context: Magnesium sulphate (MgSO4) has been studied for its beneficial role in traumatic brain injury (TBI) and ischaemic cerebral infarcts as it decreases the oxidative stress and increases the cerebral perfusion. The present study was done for evaluating its role in tuberculous meningitis (TBM). Aims: To study the role of intravenous magnesium sulphate in tuberculous meningitis. Methods and Material: The present study had 40 cases of tuberculous meningitis which comprised of 20 cases of group A(n-20) as contols for the study group B (n-20). The study group (Group B) was given intravenous magnesium sulphate 2 gm six hourly for 7 days additionally than the control group (Group A) which was treated with steroids and anti-tubercular drugs. The outcome was measured by using the Barthel Index (BI) and the Modified Rankin Scale (MRS) on the first day, the seventh day and after six weeks. The cases with arteritis in the two groups were compared separately. Statistical analysis: The results were analyzed by using the SPSS software and the unpaired t-test with p-values. Results: The means of the changes in the MRS and the BI of the Groups A and B were not statistically significant. When the means of the changes in the BI and the MRS were compared in the arteritis cases of the two groups separately, they were found to be statistically significant with a p value <0.05. Conclusions: Magnesium sulphate had a statistically significant role in TBM with tuberculous arteritis and it had a statistically nonsignificant role in TBM without arteritis.
机译：背景：硫酸镁（MgSO4）对创伤性脑损伤（TBI）和缺血性脑梗死具有有益作用，因为它降低了氧化应激并增加了脑灌注，因此已被研究。本研究旨在评估其在结核性脑膜炎（TBM）中的作用。目的：研究静脉注射硫酸镁在结核性脑膜炎中的作用。方法与材料：本研究共收治结核性脑膜炎40例，其中A组（n-20）20例为B组（n-20）的对照。研究组（B组）与接受类固醇和抗结核药物治疗的对照组（A组）相比，每6小时一次静脉注射硫酸镁2 gm，共7天。在第一天，第七天和六周后使用Barthel指数（BI）和改良兰金量表（MRS）评估结局。分别比较两组的动脉炎病例。统计分析：使用SPSS软件和带有p值的未配对t检验分析结果。结果：A组和B组的MRS和BI改变的平均值均无统计学意义。当分别比较两组的动脉炎病例中BI和MRS的变化均值时，发现它们具有统计学意义，p值<0.05。结论：硫酸镁在患有结核性动脉炎的TBM中具有统计学意义，而在无动脉炎的TBM中具有统计学意义。

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