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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Study on the Usage Pattern of Antimicrobial Agents for the Prevention of Surgical Site Infections (SSIs) in a Tertiary Care Teaching Hospital
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A Study on the Usage Pattern of Antimicrobial Agents for the Prevention of Surgical Site Infections (SSIs) in a Tertiary Care Teaching Hospital

机译：三级教学医院抗菌药物预防手术部位感染的使用模式研究

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Context: Inappropriate antimicrobial use increases the incidence of drug resistance, drug toxicity and superinfections, thereby increasing the healthcare costs. Various approaches for rationalizing the antimicrobial therapy, have been suggested. Collection of baseline data on the pattern of the antimicrobial use is usually suggested as the first step in this direction, which will help in identifying the problem areas, which demand our attention.Aims: To study the usage pattern of prophylactic antimicrobials in surgical patients, in order to detect any inappropriateness concerning the selection, timing, redosing and the duration of antimicrobial administration.Settings and Design: A retrospective review of the randomly selected medical records of the general surgical cases over an 8 month period in a tertiary care teaching hospital.Methods and Material: The medical records of 258 patients who had undergone surgical procedures were verified for the appropriateness of the antimicrobial prophylaxis, with respect to the choice of the antimicrobial agent, the time of its administration, the intraoperativere dosing, and the duration of the postoperative use. The obtained data was analyzed and conclusions were drawn with the help of descriptive statistics.Results: The third generation cephalosporins were used preoperatively in all the 258(100%) patients through the intravenous route. In addition, 77(30%) patients received metronidazole or amikacin. The antimicrobials were administered half an hour to one hour before the surgery. No intraoperative redosing was given. The duration of the postoperative prophylaxis was extended to 36 hours or more in 248(96%) of the cases.Conclusions: The timing of administration of the preoperative dose was appropriate and well delegated to the operating room nurse. The intra operative dose was appropriately omitted. The main concern was the increasing use of the third generation cephalosporins and the unnecessary prolonged duration of the postoperative prophylaxis, which needed to be addressed.
机译：背景：不当使用抗菌药物会增加耐药性，药物毒性和重复感染的发生率，从而增加医疗保健成本。已经提出了各种合理化抗微生物治疗的方法。通常，建议在此方向上收集有关抗菌药物使用方式的基线数据，这将有助于识别需要我们注意的问题领域。目的：研究手术患者中预防性抗菌药物的使用方式，设置与设计：对三级教学医院随机选择的一般外科病例在8个月内的病历进行回顾性回顾。方法和材料：对258例接受外科手术的患者的病历进行了验证，以确认抗菌药物的选择，使用时间，术中用药时间和持续时间是否合适。术后使用。结果：在描述性统计的帮助下得出结论。结果：258例（100％）患者术前均通过静脉途径使用了第三代头孢菌素。此外，有77（30％）名患者接受了甲硝唑或丁胺卡那霉素。在手术前半小时到一小时服用抗菌药物。没有术中重做。 248例（96％）病例的术后预防时间延长到36小时或以上。结论：术前给药的时机适当，应适当分配给手术室护士。术中剂量适当省略。主要关注的是第三代头孢菌素的使用增加以及术后预防的不必要的延长时间，这需要解决。

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