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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Carotid Intima Media Thickness: A Predictor of the Clincal Coronary Events
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The Carotid Intima Media Thickness: A Predictor of the Clincal Coronary Events

机译：颈动脉内膜中层厚度：临床冠状动脉事件的预测。

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Background: The Carotid Intima-Media Thickness (CIMT) is a simple and an inexpensive tool which can be used to assess the cumulative effect of atherosclerotic risk factors and it is also an independent predictor of the future cardiovascular risk. Nevertheless, criticism has been raised throughout the scientific community, based on the observations which indicated a weak correlation between CIMT and coronary atherosclerosis. It has been suggested by the International Atherosclerosis Project, that the atherosclerotic process occurs at the same time in the carotid, cerebral and the coronary arteries. Measurement of the Carotid Intima-Media Thickness (CIMT) of the Common Carotid Artery (CCA) by B-mode ultrasound was found to be a suitable non-invasive method, to visualize the arterial walls and to monitor the early stages of the atherosclerotic process.Aim: This study sought to determine the usefulness of B-mode ultrasound as a non-invasive marker to examine the association between CIMT and the extent and the severity of coronary artery disease and its association with the cardiovascular risk factors, if any.Methods: A cross-sectional study was done among hundred cases and hundred age and sex matched controls who were in the age group of 30-65 years. The cases included those who had undergone coronary angiography. The controls included non-diabetic non-hypertensives with no cardiovascular risk factors. The CIMT was assessed by using a 7MHz linear array transducer. Fasting blood samples were collected for measuring the blood sugar and the lipid profiles.Results: The statistical analysis was done by using the Student?s t test and ANOVA and a p value of double vessel disease (0.91mm) >single vessel disease (0.82mm) >normal coronaries (0.65mm).Conclusion: The easy applicability and the non invasive nature of B-mode ultrasonography make it suitable for use as a surrogate endpoint for measuring the atherosclerotic burden in people with cardiovascular risk factors. Even in this present study, we found a significant association between the extent of carotid atherosclerosis which was measured by B-mode ultrasound, and the presence, its extent, or the lack of coronary atherosclerosis which was documented by coronary angiograph
机译：背景：颈动脉内膜中层厚度（CIMT）是一种简单且便宜的工具，可用于评估动脉粥样硬化危险因素的累积作用，并且也是未来心血管风险的独立预测因子。然而，基于这些发现表明CIMT与冠状动脉粥样硬化之间的相关性较弱，整个科学界对此提出了批评。国际动脉粥样硬化项目已经提出，动脉粥样硬化过程同时发生在颈动脉，大脑和冠状动脉中。通过B型超声测量颈总动脉（CCA）的颈内膜中膜厚度（CIMT）被认为是一种合适的非侵入性方法，可以使动脉壁可视化并监测动脉粥样硬化过程的早期阶段。目的：本研究旨在确定B型超声作为非侵入性标志物的有用性，以检查CIMT与冠状动脉疾病的程度和严重程度之间的关联以及与心血管危险因素的关联（如果有）。 ：对百例和年龄在30-65岁之间的年龄和性别相匹配的对照组进行了横断面研究。病例包括接受冠状动脉造影的患者。对照组包括无糖尿病，无心血管危险因素的非高血压患者。 CIMT通过使用7MHz线性阵列换能器进行评估。空腹采集血样，测定血糖和血脂。结果：采用Student？st检验和ANOVA及双血管病（p ＜0.91mm）＞单血管病（0.82mm）的p值进行统计学分析。 >正常冠状动脉（0.65毫米）。结论：B型超声检查的易用性和无创性使其适合用作测量具有心血管危险因素的人的动脉粥样硬化负担的替代终点。即使在本研究中，我们也发现在通过B型超声测量的颈动脉粥样硬化程度与通过冠状动脉造影仪记录的冠状动脉粥样硬化的存在，程度或缺乏之间存在显着相关性

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