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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Enolving Trends: Hyperbilirubinemia Among Newborns Delivered to Rh Negative Mothers in Southern India
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Enolving Trends: Hyperbilirubinemia Among Newborns Delivered to Rh Negative Mothers in Southern India

机译：令人着迷的趋势：印度南部送给Rh阴性母亲的新生儿中的高胆红素血症

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Introduction: Neonatal jaundice is the commonest abnormal physical finding in the new born nursery and hemolytic disease of the newborn (HDN) among babies born to Rh negative mothers is the most formidable etiology. During last few decades considerable evolution has been observed in this entity secondary to development of several novel preventive, diagnostic and therapeutic modalities.Objective: To study the current trends in presentation, management and outcome of hyperbilirubinemia among newborns delivered to Rh negative mothers. Methodology: This observational descriptive study with prospective data collection included one hundred live born term babies born to Rh negative mothers in our hospital. A predesigned proforma was used to record antenatal and postnatal data .Cord blood collected during delivery for assessment of bilirubin,hematocrit and direct coombs test.Serum bilirubin levels were estimated in babies with clinical jaundice and treated for the same if required.All babies were regularly followed up weekly for one month. Chi square test/Fisher Exact test and Student ?t? test has been used to find the significant association of jaundice(incidence,treatment) and study characteristics.Results: Out of 100 babies enrolled, 57 babies developed jaundice. Jaundice is 2.7 times more likely associated with babies born to multiparous Rh-ve mothers with p=0.017*. Jaundice is 3 times more likely associated with Rh+ve babies born to multiparous mothers with p=0.020*. Jaundice is 3.97 times more likely associated with Rh+ve babies born to multiparous mothers who have not received Anti-D with p=0.154. Treatment of jaundice is 2.75 times more likely in Rh+ve babies born to multiparous mothers who have not received Anti-D with p=0.162. Duration of phototherapy is significantly more in Rh+ve babies born to multiparous mothers who had not received Anti-D with p=0.0097*.Exchange transfusion was required in two babies.Conclusion: Although the incidence of Rh isoimmunization has declined dramatically over the years ,it is still an important cause of neonatal morbidity and mortality emphasizing the need for more vigorous preventive efforts and up-to-date management skills.
机译：简介：新生儿黄疸是新生儿托儿所中最常见的异常体征，而Rh阴性母亲所生婴儿中的新生儿溶血病（HDN）是最可怕的病因。在过去的几十年中，该实体在观察到继一些新型的预防，诊断和治疗方式的发展之后发生了可观的演变。目的：研究分娩给Rh阴性母亲的新生儿高胆红素血症的表现，治疗和预后的当前趋势。方法：这项具有前瞻性数据收集的观察性描述性研究包括了我院Rh阴性母亲所生的100个活产足月婴儿。使用预先设计的形式记录产前和产后数据。分娩时收集的血液用于评估胆红素，血细胞比容和直接Coombs测试。对患有临床黄疸的婴儿评估血清胆红素水平，并在需要时进行相同治疗。所有婴儿定期每周随访一个月。卡方检验/ Fisher精确检验和学生成绩？结果：在100例婴儿中，有57例患了黄疸。该试验已用于发现黄疸（发病率，治疗）与研究特征之间的显着相关性。黄疸是多胎Rh-ve母亲所生婴儿的2.7倍，p = 0.017 *。黄疸与多胎母亲所生的Rh + ve婴儿相关的可能性是p = 0.020 *的3倍。黄疸与未接受Anti-D且p = 0.154的多胎母亲所生Rh + ve婴儿发生关系的可能性高3.97倍。在未接受抗-D治疗的多胎母亲出生的Rh + ve婴儿中，黄疸的治疗可能性高2.75倍，p = 0.162。多胎母亲未接受抗-D治疗的Rh + ve婴儿的光疗时间明显更长，p = 0.0097 *。两个婴儿需要交换输血。结论：尽管多年来Rh同种免疫的发生率显着下降，它仍然是新生儿发病率和死亡率的重要原因，强调需要更强有力的预防措施和最新的管理技能。

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