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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Apolipoprotein E Gene Polymorphism And Its Effect On Plasma Lipids In Arteriosclerosis
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Apolipoprotein E Gene Polymorphism And Its Effect On Plasma Lipids In Arteriosclerosis

机译：载脂蛋白E基因多态性及其对动脉硬化血浆脂质的影响

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Background & objectives: Myocardial infarction and stroke are leading causes of death worldwide. Primarily, arteriosclerosis is responsible for these events. There is a strong family history suggesting a genetic cause. Apolipoprotein E (apo E) plays an important role in lipid metabolism. Apo E is polymorphic with three isoforms, ApoE2, ApoE3 and ApoE4; which translate into three alleles of the gene. Its polymorphism may be a risk determinant of atherosclerosis.Methods: Lipoprotein concentrations were studied, in 100 myocardial infarction and 50 cerebrovascular stroke subjects and compared with age and sex matched controls. Genotypes for apo E isoforms (E2, E3, and E4) for all above subjects and age and sex matched controls were determined by Multiplex Amplification Refractory Mutation System PCR.Results: There were statistically significant higher values of serum total cholesterol and LDL cholesterol in study group, as compared to control group. Study of Apo E isoforms revealed higher proportion of E4 allele in the study group as compared to control group. The occurrence of each allele frequency in study and control group was E4E4: 28.66% and 16.0%, E3E3: 39.33% and 56.66%, E4E3: 14.66% and 9.33%, E3E2: 8.66% and 10.66%, E4E2: 4.66% and 2.66% & for E2E2: 4.0% and 4.66% respectively.Interpretation & Conclusion: There were significantly higher levels of serum total cholesterol, LDL cholesterol and triglyceride with E4 allele; when compared with in the study group and between study group and control group. Apo E polymorphism influences serum lipid levels and is an independent risk determinant of arteriosclerosis.
机译：背景与目的：心肌梗塞和中风是世界范围内主要的死亡原因。首先，动脉硬化是造成这些事件的原因。有很强的家族史提示遗传原因。载脂蛋白E（apo E）在脂质代谢中起重要作用。 Apo E是具有三种同工型ApoE2，ApoE3和ApoE4的多态性;转化为该基因的三个等位基因。方法：在100例心肌梗塞和50例脑血管卒中患者中研究了脂蛋白的浓度，并与年龄和性别相匹配的对照组进行了比较。通过多重扩增难治性突变系统PCR确定上述所有受试者以及年龄和性别相匹配的对照的apo E同工型（E2，E3和E4）的基因型。结果：研究中血清总胆固醇和LDL胆固醇的统计值较高，具有统计学意义组，与对照组相比。对Apo E亚型的研究表明，与对照组相比，研究组中E4等位基因的比例更高。研究和对照组中每个等位基因频率的发生率分别为E4E4：28.66％和16.0％，E3E3：39.33％和56.66％，E4E3：14.66％和9.33％，E3E2：8.66％和10.66％，E4E2：4.66％和2.66 E2E2的％和分别为4.0％和4.66％。解释与结论：E4等位基因的血清总胆固醇，LDL胆固醇和甘油三酸酯水平显着升高;与研究组中以及研究组和对照组之间比较时。 Apo E基因多态性影响血清脂质水平，是动脉硬化的独立危险因素。

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