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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood
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Lipid Peroxidation and the Total Antioxidant Status in the Pathogenesis of Age Related and Diabetic Cataracts: A Study on the Lens and Blood

机译：年龄相关性和糖尿病性白内障发病机理中的脂质过氧化和总抗氧化状态：晶状体和血液的研究

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Background: Cataract is one of the major causes of a visual impairment, which eventually leads to blindness. An oxidative damage to the lens proteins is a major factor which leads to cataract formation. Therefore, we intended to study the relationship between the biochemical markers of oxidative stress and various forms of cataracts.Methods: We examined the lenses and the sera of 120 subjects who were aged 50 to 80 years, who were distributed in two groups, viz. the study group (90 patients) and the control group (30 subjects). The oxidative stress was assessed by estimating the lipid peroxidation product in the form of thiobarbituric acid reactive substances (TBARS), the antioxidant status by measuring the levels of vitamin E and the total antioxidant capacity (TAC). The study group patients were further divided into those with nuclear cataracts (30 patients), cortical cataracts (30 patients), and diabetic cataracts (30 patients).Results: In this study, it was found that the levels of TBARS in the study group were significantly high (p<0.001), whereas the TAC (p<0.001) and the vitamin E (p<0.001) levels were significantly low, both in the lenses and the blood of the study group as compared to those of the control group.Conclusion: Thus, the present study suggests that an imbalance between the oxygen free radicals and the antioxidants may lead to lipid peroxidation in the lens. Also, the elevated levels of glucose in the diabetic cataracts lead to the auto-oxidation of glucose and a non-enzymatic glycation of the lens protein. Thereby, the high molecular weight proteins aggregate in the cataract.
机译：背景：白内障是导致视力障碍的主要原因之一，视力障碍最终导致失明。晶状体蛋白质的氧化损伤是导致白内障形成的主要因素。因此，我们打算研究氧化应激的生化标志物与各种形式的白内障之间的关系。方法：我们检查了120例年龄在50至80岁的受试者的晶状体和血清，将其分为两组。研究组（90名患者）和对照组（30名受试者）。通过估计硫代巴比妥酸反应性物质（TBARS）形式的脂质过氧化产物，通过测量维生素E的水平和总抗氧化剂能力（TAC）评估抗氧化剂的状态来评估氧化应激。研究组患者进一步分为核性白内障（30例），皮质性白内障（30例）和糖尿病性白内障（30例）。结果：本研究发现，研究组中的TBARS水平与对照组相比，研究组的晶状体和血液中的TAC（p <0.001）显着高（p <0.001），而维生素E（p <0.001）的TAC（p <0.001）显着低结论：因此，本研究表明氧自由基和抗氧化剂之间的不平衡可能导致晶状体脂质过氧化。而且，糖尿病性白内障中葡萄糖水平的升高导致葡萄糖的自动氧化和晶状体蛋白的非酶促糖基化。因此，高分子量蛋白聚集在白内障中。

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