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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Retrospective Audit of the Widal Test for Diagnosis of Typhoid Fever in Pediatric Patients in an Endemic Region
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Retrospective Audit of the Widal Test for Diagnosis of Typhoid Fever in Pediatric Patients in an Endemic Region

机译：流行区儿科病人诊断性肺炎试验的回顾性检查的回顾性审核

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Introduction:Although typhoid fever is confirmed by culture of Salmonella Typhi , Widal test is widely used in India but little information exists about its reliability.Materials and Methods:We examined the performance of Widal test in our hospital for diagnosis of typhoid fever in children. Hundred consecutive pediatric in-patients for whom, the Widal test was requested were grouped into four categories: widal positive and clinically consistent with typhoid fever (Group 1; n=42), widal negative but clinically consistent (Group 2, n=12), widal positive but not clinically consistent (Group 3, n=12) and widal negative and also not clinically consistent (Group 4, n=34). The results were analyzed by the test performance criteria, namely, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) using culture-confirmed typhoid fever cases as the ?true positives?.Results:We found that 7/100 patients had culture-proven typhoid fever. Using a cut off = 50 for O agglutinins or = 100 for H agglutinins, the Widal test gave a sensitivity of 71.43%, specificity of 47.31%, and a positive predictive value of 09.25% and a negative predictive value of 95.65%.Conclusion:The Widal test is an easy, inexpensive and relatively non-invasive but is not reliable in our set up because of a low PPV. There is a need for a more efficient rapid diagnostic test for typhoid fever.
机译：简介：尽管伤寒是由伤寒沙门氏菌培养证实的，但维达尔试验在印度已广泛使用，但其可靠性尚缺乏信息。材料与方法：我们在我院检查了维达尔试验在诊断儿童伤寒中的表现。连续数百名需要进行Widal测试的儿科患者分为四类：呈阳性且临床与伤寒相符的（第1组; n = 42）;呈阴性但具有临床一致性的（第2组，n = 12）。 ，Widal阳性但临床上不一致（第3组，n = 12）和widal阴性且临床上也不一致（第4组，n = 34）。结果以培养证实的伤寒病例为“真阳性”，通过敏感性，特异性，阳性预测值（PPV）和阴性预测值（NPV）等测试表现标准进行分析。结果：我们发现7 / 100位患者患有经文化证明的伤寒。使用O凝集素的临界值= 50或H凝集素的临界值= 100，维达尔试验的敏感性为71.43％，特异性为47.31％，阳性预测值为09.25％，阴性预测值为95.65％。 Widal测试是一种简单，便宜且相对无创的测试，但由于PPV较低，因此在我们的设置中不可靠。需要针对伤寒的更有效的快速诊断测试。

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