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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prevalence of Co-existing Endometrial Carcinoma in Patients with Preoperative Diagnosis of Endometrial Hyperplasia
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Prevalence of Co-existing Endometrial Carcinoma in Patients with Preoperative Diagnosis of Endometrial Hyperplasia

机译：子宫内膜增生的术前诊断中共存子宫内膜癌的患病率

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Introduction: Endometrial hyperplasia has been associated with the presence of concomitant endometrial carcinoma. In this study, patients who were diagnosed with endometrial hyperplasia and had hysterectomy, determination of the incidence of endometrial cancer accompanying postoperatively and clinical parameters associated with cancer are aimed. Materials and Methods: Endometrial biopsies were taken from patients for various reasons and among them 158 patients diagnosed with endometrial hyperplasia from pathologic examination results were retrospectively evaluated. All of the patient?s age, parity, weight, transvaginal ultrasound measured by endometrial thickness, concomitant systemic disease (diabetes, hypertension, hypothyroidism), tamoxifen use, hormone use and whether in reproductive age or menopause were all questioned. Patients who applied with endometrial cancer, their cervical stromal involvement, lymph node involvement, cytology positivity and omental metastases were examined. Patients were classified according to their stage and grade. Patients who had intraoperative frozen were re-evaluated. Results: Fifteen cases with preoperative endometrial hyperplasia diagnosed with endometrial cancer postoperatively, 2 cases had complex hyperplasia without atypia and 13 cases had complex atypical hyperplasia. The rate of preoperative hyperplasia with postoperative endometrial cancer was found to be 10.8% where by 15 cases of patients diagnosed with endometrial cancer postoperatively 11 cases were in postmenopausal period. In patients diagnosed with endometrial cancer according to their histologic types 14 cases had endometrioid adenocarcinoma while one patient with preoperative complex hyperplasia without atypia was diagnosed with serous papillary carcinoma postoperatively. Evaluation of stages in patients diagnosed with cancer, 7 cases of patients had stage IA, 7 cases of patients had stage IB, and 7 cases cases of patients with serous papillary carcinoma were evaluated as stage 3C. Conclusion: The risk of endometrial cancer in patients diagnosed with endometrial hyperplasia especially endometrial hyperplasia ranges between 15% to 45% and among them 7.9%?51% are found to have myometrial inversion. Therefore, preoperative ultrasound and magnetic resonance imaging should be perfomed in patients diagnosed with complex atypical hyperplasia. Even intraoperative frozen section examination can provide useful information in selected cases.
机译：简介：子宫内膜增生与伴有子宫内膜癌有关。在这项研究中，目标是诊断出子宫内膜增生并行子宫切除术的患者，确定伴随手术的子宫内膜癌的发生率以及与癌症相关的临床参数。材料与方法：出于各种原因对患者进行子宫内膜活检，并回顾性评估其中158例经病理检查诊断为子宫内膜增生的患者。所有患者的年龄，胎次，体重，通过子宫内膜厚度，伴随系统性疾病（糖尿病，高血压，甲状腺功能减退），他莫昔芬的使用，激素的使用以及是否处于生育年龄或更年期的阴道超声检查均受到质疑。检查了应用子宫内膜癌的患者，宫颈间质受累，淋巴结受累，细胞学阳性和网膜转移。根据患者的阶段和等级对其进行分类。对术中冷冻的患者进行重新评估。结果：15例术前子宫内膜增生被诊断为子宫内膜癌，2例无异型的复杂性增生，13例有异型的非典型增生。术后子宫内膜癌的术前增生率为10.8％，其中有15例术后子宫内膜癌的患者中有11例处于绝经期。根据组织学类型诊断为子宫内膜癌的患者中有14例患有子宫内膜样腺癌，而一名术前复杂性增生且无异型的患者术后被诊断为浆液性乳头状癌。将诊断为癌症的患者的阶段，7例IA期患者，7例IB期患者和7例浆液性乳头状癌患者评估为3C期。结论：诊断为子宫内膜增生，特别是子宫内膜增生的患者子宫内膜癌的风险范围在15％至45％之间，其中7.9％？51％被发现有子宫肌层倒置。因此，诊断为复杂的非典型增生的患者应进行术前超声和磁共振成像检查。甚至术中冰冻切片检查也可以在某些情况下提供有用的信息。

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