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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Estimation and Comparison of Salivary Calcium, Phosphorous, Alkaline Phosphatase and pH Levels in Periodontal Health and Disease: A Cross-sectional Biochemical Study
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Estimation and Comparison of Salivary Calcium, Phosphorous, Alkaline Phosphatase and pH Levels in Periodontal Health and Disease: A Cross-sectional Biochemical Study

机译：牙周健康和疾病中唾液钙，磷，碱性磷酸酶和pH值的估计和比较：横断面生化研究

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Introduction: In oral diagnostics there is a great challenge to determine biomarkers for screening and evaluating the disease activity. Biomarkers can also serve as a useful tool to measure the efficacy of the therapy. Aim: To evaluate and compare the levels of salivary calcium, phosphorous, alkaline phosphatase and pH levels in periodontally healthy subjects and patients with gingivitis and periodontitis. Materials and Methods: The present study consisted of 150 subjects aged between 20-45 years who were divided into three groups; periodontally healthy, gingivitis and chronic periodontitis. Prior to the clinical examination the demographic details, relevant information of the subject, gingival index, plaque index, Oral Hygiene Index (OHI) and pH were recorded. Biochemical assay of saliva i.e., inorganic calcium, phosphorous and alkaline phosphatase were estimated by colorimetric method. ANOVA and Tukey?s test were applied for statistical analysis. Results: The mean levels of biomarkers studied were; inorganic calcium (12.55μg/dl), phosphorous (14.50μg/dl), alkaline phosphatase (49.62μg/dl) and pH (11.65). There was a gradual increase in these levels as the condition progressed from health to gingivitis or periodontitis which was statistically significant at p<0.001. Conclusion: Based on these results, it can be concluded that, the biomarkers like salivary calcium, phosphorous, alkaline phosphatase and pH can be considered for evaluating the diagnosis and prognosis of periodontal tissues in disease and health.
机译：简介：在口腔诊断中，确定用于筛选和评估疾病活动的生物标志物面临着巨大挑战。生物标志物也可以用作测量治疗功效的有用工具。目的：评估和比较牙周健康受试者以及牙龈炎和牙周炎患者的唾液钙，磷，碱性磷酸酶和pH值水平。材料和方法：本研究由150名年龄在20-45岁之间的受试者组成，他们分为三组;每组包括3名受试者。牙周健康，牙龈炎和慢性牙周炎。在进行临床检查之前，应记录人口统计学细节，受试者的相关信息，牙龈指数，牙菌斑指数，口腔卫生指数（OHI）和pH。用比色法估算唾液的生化含量，即无机钙，磷和碱性磷酸酶。方差分析和Tukey检验用于统计学分析。结果：研究的生物标志物的平均水平为：无机钙（12.55μg/ dl），磷（14.50μg/ dl），碱性磷酸酶（49.62μg/ dl）和pH（11.65）。随着疾病从健康发展到牙龈炎或牙周炎，这些水平逐渐增加，这在p <0.001上具有统计学意义。结论：根据这些结果，可以得出结论，唾液钙，磷，碱性磷酸酶和pH等生物标记物可用于评估牙周组织在疾病和健康中的诊断和预后。

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