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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Isoniazid Induced Lupus Presenting as Oral Mucosal Ulcers with Pancytopenia
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Isoniazid Induced Lupus Presenting as Oral Mucosal Ulcers with Pancytopenia

机译：异烟肼诱导的狼疮表现为全血细胞减少症的口腔粘膜溃疡

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摘要

Drug Induced Lupus Erythematous (DILE) is a rare adverse reaction to a large variety of drugs including Isoniazid (INH), with features resembling idiopathic Systemic Lupus Erythematosus (SLE). Diagnosis require identification of a temporal relationship between drug administered and symptom. It is an idiosyncratic reaction, with no pre-existing lupus. Our case highlights a rare presentation of isoniazid induced lupus with profound pancytopenia and mucosal ulcers, thus posing a diagnostic challenge. The patient was on multidrug treatment for pulmonary and knee joint tuberculosis. DILE was diagnosed on basis of strongly positive Anti Nuclear Antibodies (ANA), anti ds DNA and antihistone antibodies with clinical response to cessation of INH.
机译：药物诱发的红斑狼疮（DILE）是对包括异烟肼（INH）在内的多种药物的罕见不良反应，其特征类似于特发性系统性红斑狼疮（SLE）。诊断需要确定所用药物与症状之间的时间关系。这是一种特异反应，没有狼疮。我们的病例强调了异烟肼诱导的狼疮的罕见表现，并伴有严重的全血细胞减少和粘膜溃疡，因此对诊断提出了挑战。该患者正在接受多种药物治疗肺结核和膝关节结核。根据强烈的抗核抗体（ANA），抗ds DNA和抗组蛋白抗体对DILE进行诊断，并对INH的戒断做出临床反应。

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