...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparative Evaluation of Ciprofloxacin Levels in GCF and Plasma of Chronic Periodontitis Patients: Quasi Experimental Study
【24h】

Comparative Evaluation of Ciprofloxacin Levels in GCF and Plasma of Chronic Periodontitis Patients: Quasi Experimental Study

机译：慢性牙周炎患者GCF和血浆中环丙沙星水平的比较评价：拟实验研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: For any antimicrobial approach to be successful in periodontal therapy, it is important that the antimicrobial agent targets the sub-gingival biofilm by attaining sufficient concentration at the sub-gingival site. Aim: The purpose of the present study was to determine and compare the concentrations of ciprofloxacin present in Gingival Crevicular Fluid (GCF) and plasma after its systemic administration. Materials and Methods: A total of 20 subjects, in the age group of 30-60 years satisfying the inclusion and exclusion criteria, were chosen from the outpatient Department of Periodontology, Government Dental College and Hospital, Hyderabad and consent was obtained. Subjects were put on oral ciprofloxacin therapy (Baycip, Bayer Corporation) of 500mg twice daily doses for five days to establish steady state tissue levels of the agent. GCF and serum samples were collected at the 72nd hour after the first dose of ciprofloxacin and were compared using unpaired t test. Results: The mean gingival index value of the subjects was 1.8 ± 0.59 and the mean probing depth of the subjects taken in the study was 5.724 ± 0.47mm. The results of this study showed that ciprofloxacin concentrations were significantly higher (p<0.001) in GCF than in plasma. Conclusion: Results from the present study and those from the earlier studies clearly indicate the ciprofloxacin?s ability to reach and concentrate in infected periodontal sites via GCF. This property of ciprofloxacin may be useful for eradication of periodontal pathogens, thus improving the outcome of periodontal therapy.
机译：简介：为了使任何抗菌方法在牙周治疗中取得成功，重要的是，抗菌剂应通过在牙龈下部位获得足够的浓度来靶向牙龈下生物膜。目的：本研究的目的是确定并比较全身给药后牙龈沟液（GCF）和血浆中环丙沙星的浓度。材料与方法：从海得拉巴政府牙科学院和医院的门诊部牙周病科中选出了20名年龄在30至60岁之间的年龄组，满足纳入和排除标准，并获得了同意。将受试者每天两次口服500mg环丙沙星治疗（Baycip，Bayer Corporation），持续五天，以建立该药剂的稳态组织水平。首次服用环丙沙星后第72小时收集GCF和血清样品，并使用未配对t检验进行比较。结果：研究对象的平均牙龈指数值为1.8±0.59，研究对象的平均探测深度为5.724±0.47mm。这项研究的结果表明，GCF中的环丙沙星浓度显着高于血浆中的浓度（p <0.001）。结论：本研究和较早研究的结果清楚地表明环丙沙星通过GCF到达并集中在感染牙周部位的能力。环丙沙星的这种特性可能对根除牙周病原体有用，从而改善了牙周治疗的效果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号