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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Assessment of Insulin Sensitivity and its Convalescence with Dietary Rehabilitation in Undernourished Rural West Bengal Population LC29-LC32
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Assessment of Insulin Sensitivity and its Convalescence with Dietary Rehabilitation in Undernourished Rural West Bengal Population LC29-LC32

机译：营养不良的西孟加拉邦农村人口LC29-LC32的胰岛素敏感性及其恢复与饮食恢复的评估

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Introduction: Metabolic syndrome involving diabetes is acquiring the eminence of prospective epidemic in India with dramatic rise in rural population prevalence where majority are undernourished and creates significant healthcare burden.Aim: To investigate the prevalence of the insulin resistance amongst the undernourished rural population, involving children, adolescents and adult volunteers of the West Bengal and the effect of nutritional supplementation in the parameters echoing insulin sensitivity.Materials and Methods: A prospective interventional study was carried out on 120 volunteers in three age groups; Group 1 (5-12 years), Group 2 (13-18 years) and Group 3 (19-40 years), each with 40 subjects who fulfilled the inclusion criteria, under informed consent over six months. Baseline data regarding demography, family history including parental history of diabetes, medical history, physical, activity, anthropometrical status and blood parameters echoing insulin sensitivity were obtained from volunteers. Intervention included daily nutritional supplementation with eggs and banana. After six months of food supplementation, parameters reflecting insulin sensitivity were assessed.Results: Initial low figures of fasting insulin and blood sugar levels improvised with the nutritional supplementation alongside the absence of wasting in Group 1. HOMA-IR and IRI values of the Group 2 improved from the initial figures (3.19, 2.87) to (2.204, 1.99) and that of Group 3 from (5.0, 4.52) to (4.08, 3.67) respectively over six months (p<.05). Average Fasting Blood Sugar (FBS) enhanced from 85.5±9.6 mg/dl to 78.4±7.3 mg/dl and from 90.1±10.2 mg/dl to 84.8±8.4 mg/dl in Group 2 and 3 respectively by the end of the supplementation study (p<.05).Conclusion: Six months study revealed the existence of insulin resistance and malnourishment in the selected rural population in three groups. Decrement in HOMA-IR, IRI, FBS and serum insulin alongside the improvement in the body mass, in comparison to that of initial values is evocative of restoration of insulin sensitivity with nutrition supplementation.
机译：简介：涉及糖尿病的代谢综合症在印度正逐渐流行开来，农村人口患病率急剧上升，多数人口营养不良并造成重大的医疗负担。材料和方法：对三个年龄段的120名志愿者进行了一项前瞻性干预研究;前者是西孟加拉邦的青少年，成年志愿者，而营养补充剂在参数上的影响也与胰岛素敏感性相呼应。第1组（5-12岁），第2组（13-18岁）和第3组（19-40岁），每个人都有40名符合入选标准的受试者，并在六个月内获得知情同意。从志愿者那里获得了有关人口统计学，家族史（包括父母的糖尿病史，病史，身体，活动，人体测量状况和血液参数，与胰岛素敏感性相呼应）的基线数据。干预措施包括每日补充鸡蛋和香蕉的营养。在补充食物六个月后，评估了反映胰岛素敏感性的参数。结果：在第1组中，营养补充剂改善了空腹胰岛素和血糖水平的最初低数字，同时没有浪费。第2组的HOMA-IR和IRI值在六个月内，从最初的数字（3.19，2.87）改善到（2.204，1.99），第三组的数字从（5.0，4.52）改善到（4.08，3.67）（p <.05）。补充研究结束时，第2组和第3组的平均空腹血糖（FBS）从85.5±9.6 mg / dl增加到78.4±7.3 mg / dl，从90.1±10.2 mg / dl增加到84.8±8.4 mg / dl （p <.05）。结论：六个月的研究表明，三组选定的农村人口存在胰岛素抵抗和营养不良。与初始值相比，HOMA-IR，IRI，FBS和血清胰岛素的减少与体重的改善相提并论，通过营养补充可以恢复胰岛素敏感性。

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