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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Spectrum of Complications of Chronic Liver Disease in Gauhati Medical College and Hospital: A Hospital Based Study
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Spectrum of Complications of Chronic Liver Disease in Gauhati Medical College and Hospital: A Hospital Based Study

机译：高哈蒂医学院和医院的慢性肝病并发症频谱：基于医院的研究

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Cirrhosis of liver is defined anatomically as a diffuse process with nodule formation and fibrosis. Cirrhosis can remain as a silent disease until decompensation occurs. The clinical features are the result of the pathological changes and they mirror the severity of the liver disease and they are the same irrespective of the cause. Decompensated disease can result in complications such as as cites, spontaneous bacterial peritonitis, hepatic encephalopathy and variceal bleeding from portal hypertension. Data regarding the aetiology and the spectrum of clinical manifestations and complications of cirrhosis of liver is lacking from the North-East, India. Against this background, this present study was conducted.Aim: To determine the clinical spectrum of patients with chronic liver disease with reference to its aetiology, clinical manifestations, complications and causes of death in Gauhati Medical College and Hospital.Materials and Methods: The cross-sectional study was carried out with 200 enrolled chronic liver disease patients. A detailed history, clinical examination and a structured questionnaire were used to collect the data. Haematological, biochemical, radiological as well as endoscopic investigations were performed to evaluate various complications and manifestations. Data was analysed and expressed as percentage.Results: Alcohol was the most common aetiological factor for cirrhosis in 62.5% patients followed by Hepatitis B in 11%, Non Alcoholic Steato Hepatitis (NASH) in 9% and Hepatitis C in 3.5%. After performing the necessary investigations, the various complications of cirrhosis were coagulopathy in 83%, gastroesophagealvarix/ portal hypertensive gastropathy in 81%, ascites in 64%, hepatic encephalopathy in 51%, hypersplenism in 24%, hyponatremia in 17.18%, spontaneous bacterial peritonitis in 12.5%, hepatorenal syndrome in 4% and hepatocellular carcinoma in 2.5%. Ascitic fluid culture was positive in 9.3% patients with ascites, the most common organism grown in culture was E. Coli. 52.5% of the patients had Child Pugh C cirrhosis and 13% died during hospital stay. The most common cause of death was worsening hepatic encephalopathy in 50% followed by UGI bleed and sepsis.Conclusion: Chronic liver disease proves to be fatal if allowed to decompensate. Therefore, the best option is to prevent it or to control it at the earliest.
机译：肝硬化在解剖学上定义为具有结节形成和纤维化的扩散过程。肝硬化可以作为无声疾病保留，直到发生代偿失调为止。临床特征是病理变化的结果，它们反映了肝病的严重程度，并且无论原因如何，它们都是相同的。代偿失调的疾病可能导致并发症，例如举证，自发性细菌性腹膜炎，肝性脑病和门脉高压引起的静脉曲张破裂出血。印度东北部缺乏有关肝硬化的病因学，临床表现和并发症范围的数据。在此背景下，进行了本研究。目的：参照高哈蒂医学院和医院的慢性肝病的病因，临床表现，并发症和死亡原因来确定其临床范围。材料和方法：这项横断面研究是针对200名入选的慢性肝病患者进行的。详细的病史，临床检查和结构化的问卷被用来收集数据。进行了血液学，生化，放射学和内窥镜检查以评估各种并发症和表现。 结果：酒精是导致肝硬化的最常见病因，在62.5％的患者中，其次是乙型肝炎，占11％，非酒精性脂肪性肝炎（NASH），占9％，丙型肝炎，在3.5％ 。经过必要的检查后，肝硬化的各种并发症为：凝血病83％，胃食管/门脉高压性胃病81％，腹水64％，肝性脑病51％，脾功能亢进24％，低钠血症17.18％，自发性细菌性腹膜炎肝肾综合征占12.5％，肝肾综合征占4％，肝细胞癌占2.5％。 9.3％的腹水患者的腹水培养呈阳性，培养物中最常见的生物是大肠杆菌。 52.5％的患者患有Child Pugh C肝硬化，13％的患者在住院期间死亡。最常见的死亡原因是50％的肝性脑病恶化，然后是UGI出血和败血症。结论：如果允许代偿失调，慢性肝病被证明是致命的。因此，最好的选择是预防或尽早控制它。

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