Pyridoxine: The ?Ba.Six? of use in Nausea and Vomiting of Pregnancy

Abbas Hassan; Arun Kumar Dubey; Malpe Surekha Bhat

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Pyridoxine: The ?Ba.Six? of use in Nausea and Vomiting of Pregnancy

机译：吡rid醇：Ba.6？恶心中的使用和妊娠呕吐

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Over the centuries, the dietary and biochemical essentiality of pyridoxine in the humans has been well established. Apart from various physiological functions, pyridoxine is therapeutically important in Nausea and Vomiting of Pregnancy (NVP). Pyridoxine on its own or a combination of pyridoxine (vitamin B6) (pregnancy category A) and doxylamine (category B), previously available as Bendectin, is the only medication that is specifically labeled for the treatment of NVP by the Food and Drug Administration. Although various reports claims the efficacy of pyridoxine in NVP, there are a very few studies on its mechanism of action in relieving the symptoms. Therefore, the present review was aimed at revisiting relevant previous data and providing the necessary background to discuss the chemistry, pharmacochemistry, status in pregnancy and mechanism/s of action in NVP of this B-complex vitamin in detail.

机译：几个世纪以来，人们已经确定吡in醇在饮食和生化方面的重要性。除多种生理功能外，吡ido醇在恶心和妊娠呕吐（NVP）中也具有治疗重要性。吡醇本身或吡ido醇（维生素B6）（妊娠A类）和多西拉敏（B类）的组合（以前可作为Bendectin使用）是食品和药物管理局唯一专门标记为治疗NVP的药物。尽管各种报道声称吡ido醇在NVP中具有疗效，但有关其缓解症状的作用机理的研究很少。因此，本综述旨在回顾相关的先前数据，并提供必要的背景来详细讨论这种B型复合维生素的化学，药物化学，妊娠状况以及NVP的作用机理。

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《Journal of Clinical and Diagnostic Research》 |2019年第5期|共6页
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Abbas Hassan; Arun Kumar Dubey; Malpe Surekha Bhat;
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中图分类临床医学;
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1. Pyridoxine: The ?Ba.Six? of use in Nausea and Vomiting of Pregnancy [J] . Abbas Hassan, Arun Kumar Dubey, Malpe Surekha Bhat Journal of Clinical and Diagnostic Research . 2019,第5期

机译：吡rid醇：Ba.6？恶心中的使用和妊娠呕吐
2. Comparing pyridoxine and doxylamine succinate-pyridoxine HCl for nausea and vomiting of pregnancy: A matched, controlled cohort study [J] . Pope Eliza, Maltepe Caroline, Koren Gideon The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2015,第7期

机译：比较吡ido醇和多西拉敏琥珀酸-吡rid醇盐酸盐对恶心和呕吐的影响：一项配对对照研究
3. Pregnancy Outcomes in Women with Nausea and Vomiting of Pregnancy (NVP) Treated with Delayed-Release Combination of Doxylamine/Pyridoxine (Diclectin/Diclegis) [J] . Madjunkova Svetlana, Maltepe Caroline, Koren Gideon Birth defects research, Part A. Clinical and molecular teratology . 2014,第7期

机译：多西拉敏/吡rid醇（Diclectin / Diclegis）延迟释放联合治疗恶心和呕吐（NVP）妇女的妊娠结局
4. Effect of Ginger Drinks on Nausea Vomiting in The First Trimester of Pregnancy [C] . P A Kusumawardani, S Cholifah, M T Multazam Annual Applied Science and Engineering Conference . 2018

机译：姜饮料对怀孕孕中期恶心呕吐的影响
5. A Clinical Decision Tool to Guide Prevention of Adult Postoperative Nausea and Vomiting During Ondansetron Shortages [D] . Bernal, Diana Isabel. 2020

机译：导致预防成人术后恶心的临床决策工具，ondansetron短缺期间呕吐
6. Demonstration of early efficacy results of the delayed-release combination of doxylamine-pyridoxine for the treatment of nausea and vomiting of pregnancy [O] . Gideon Koren, Shannon Clark, Gary D. V. Hankins, 2016

机译：证明多西拉敏-吡rid醇缓释组合治疗恶心和呕吐的早期疗效结果
7. Chemotherapy is one of the therapies for cancer patients that cause some side effects, one of them is nausea and vomiting. Nausea and vomiting are still felt by patients even though they take antiemetics. Nausea dan vomiting can cause fluid and electrolyte imbalance. The aim of this study was to analysis the effect of combination acupressure wristband and antiemetic among chemotherapy induced nausea vomiting (CINV) on breast cancer patients. This research used quasi experimental research method, with a pre-post test with the control group. The sampling techniques was consecutive sampling with 25 respondents both in intervention group and control group. In the intervention group had received an acupressure wristband. CINV measured on the second day until fourth day after chemotherapy. Nausea and vomiting score were measured twice a day by a telemonitoring methode by Rhodes Index Nausea, Vomiting and Retching (INVR) questionaire. Data were analyzed by paired t-test, independent t-test, Wilcoxon test and Mann Whitney. The result of this study showed that acupressure wristband significantly reduce the chemotherapy induced nausea and vomit (p value = 0.000). The use of acupressure wristband combined with antiemetic therapy can significantly decrease chemotherapy induced nausea and vomiting in breast cancer patients. Acupressure wristband recommended for consideration nursing intervention in treating breast cancer patients who experience nausea and vomiting. [O] . Endah Fatma 2018

机译：化疗是癌症患者的疗法之一，导致一些副作用，其中一个是恶心和呕吐。患者仍然感受到恶心和呕吐，即使他们服用助性学。恶心丹呕吐会导致液体和电解质不平衡。本研究的目的是分析组合组合腕带和抑制在乳腺癌患者中的诱导恶心呕吐（CINV）的影响。本研究使用了准实验研究方法，用对照组进行了预先测试。采样技术是在干预组和对照组中进行25名受访者的连续抽样。在干预组中，收到了一名腕带。 Cinv在化疗后第四天测量。通过罗得岛指数恶心，呕吐和转换（INVR）问卷，每天测量恶心和呕吐分数。通过配对的T检验，独立的T检验，Wilcoxon测试和Mann Whitney分析数据。该研究的结果表明，Acuruce腕带显着降低化疗诱导的恶心和呕吐物（P值= 0.000）。使用Acu压抑腕带与止吐疗法相结合，可以显着降低乳腺癌患者诱导的恶心和呕吐。 Acu压痕腕带推荐用于治疗体验恶心和呕吐的乳腺癌患者的护理干预。

Pyridoxine: The ?Ba.Six? of use in Nausea and Vomiting of Pregnancy

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