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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile Among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry
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Evaluation of Effect of Antiepileptic Drugs on Serum Lipid Profile Among Young Adults with Epilepsy in a Tertiary Care Hospital in Pondicherry

机译：在庞地契里三级医院，抗癫痫药对癫痫青壮年患者血脂谱的影响评估

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Introduction: Several studies have reported that commonly used antiepileptic drugs like phenytoin, and carbamazepine increase serum High Density Lipoproteins Cholesterol (HDL-C) levels, while some others documented no such effect. Further, some researchers also observed that valproic acid and other newer antiepileptic drugs like lamotrigine and levetiracetam has no influence on serum lipid profile. The present study was planned to assess and compare serum lipid profile of young adult patients on commonly used antiepileptic drugs (phenytoin, oxcarbazepine and valproic acid) and newer antiepileptic drug (levetiracetam) attending Neurology OPD of a tertiary care hospital in Puducherry, India compared to normal subjects.Materials and Methods: A prospective hospital based cross-sectional study was conducted in Tertiary care hospital. Epileptic patients attending Department of Neurology and taking antiepileptic drugs for last six months or more and on regular follow up; approximately 60 patients on commonly used antiepileptic drugs (20 on phenytoin, 20 on oxcarbazepine, 20 on valproic Acid) and 20 patients on newer antiepileptic drug (levetiracetam) was included in the study. Age and sex matching 80 controls were taken.Statistical analysis: Descriptive statistics explained using mean ± SD. Inferential statistics was used depending on the nature of variables. We used one-way-ANOVA and followed by independent t-test for comparison with control group and statistically significant was considered at p-value <0.05. Results: We observed statistically significant high mean TC, HDL-C, LDL-C and TG levels in the group receiving phenytoin for more than six months when compared with control group. We observed statistically significant high mean TC, HDL-C and TG levels in the group receiving oxcarbazepine for more than six months when compared with control. However, no significant difference was observed in mean LDL-C levels when compared to control. We did not observe any statistically significant difference among mean TC, HDL-C, LDL-C and TG levels in the group receiving valproate. We did not observe any statistically significant difference among mean TC, HDL-C, LDL-C and TG levels in the group receiving levetiracetam.Conclusion: From the present study we can conclude that CYP enzyme inducer anti epileptic medicines like phenytoin and oxcarbazepine is strongly associated with increased levels of TC, LDL-C, HDL-C and TG where as valproate and levetiracetam showed no significant change. Therefore, the serum cholesterol level should be regularly monitored in patients undergoing therapy with inducer anti epileptic medicines.
机译：简介：几项研究报告说，常用的抗癫痫药（如苯妥英钠和卡马西平）可提高血清高密度脂蛋白胆固醇（HDL-C）的水平，而另一些则无此作用。此外，一些研究人员还观察到丙戊酸和其他较新的抗癫痫药如拉莫三嗪和左乙拉西坦对血脂水平没有影响。本研究计划评估和比较印度普多休里一家三级医院神经内科OPD的常用抗癫痫药（苯妥英，奥卡西平和丙戊酸）和较新的抗癫痫药（左乙拉西坦）的成年患者的血脂水平，材料与方法：在三级医院进行了一项基于前瞻性医院的横断面研究。进入神经内科并在过去六个月或更长时间内服用抗癫痫药并定期随访的癫痫患者;该研究包括约60例常用抗癫痫药（苯妥英钠20例，奥卡西平20例，丙戊酸20例）和新型抗癫痫药（左乙拉西坦）20例。进行年龄和性别匹配的80名对照。统计分析：描述性统计使用均数±SD进行解释。根据变量的性质使用推论统计。我们使用单因素方差分析，然后通过独立的t检验与对照组进行比较，并在p值<0.05时认为具有统计学意义。结果：与对照组相比，接受苯妥英钠治疗的组在超过六个月的时间里观察到了具有统计学意义的高平均TC，HDL-C，LDL-C和TG水平。与对照组相比，在接受奥卡西平治疗六个月以上的组中，我们观察到统计学显着的高平均TC，HDL-C和TG水平。然而，与对照相比，平均LDL-C水平没有观察到显着差异。我们没有观察到丙戊酸组的平均TC，HDL-C，LDL-C和TG水平之间有任何统计学上的显着差异。我们没有观察到接受左乙拉西坦组的平均TC，HDL-C，LDL-C和TG水平有统计学意义上的显着差异。与TC，LDL-C，HDL-C和TG的水平升高有关，丙戊酸和左乙拉西坦无明显变化。因此，接受诱导抗癫痫药物治疗的患者应定期监测血清胆固醇水平。

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