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首页> 外文期刊>Journal of Clinical and Diagnostic Research >GCF Resistin As A Novel Marker in Patients with Chronic Periodontitis and Rheumatoid Arthritis
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GCF Resistin As A Novel Marker in Patients with Chronic Periodontitis and Rheumatoid Arthritis

机译：GCF抵抗素作为慢性牙周炎和类风湿关节炎患者的新型标志物

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Background: The associational studies between periodontitis and rheumatoid arthritis are less documented, although they are found to have similar inflammatory pathogenesis. Resistin, a novel adipokine is suggested to be a common link between periodontitis and rheumatoid arthritis. The aim of the present study was to reinforce the inter-relationship between periodontitis and rheumatoid arthritis by using resistin as a potent inflammatory marker. Materials and Methods: Hundred patients (aged >30 y) of either sex were selected for this study and were divided equally into four groups of 25 patients each. Group A consisted of healthy individuals, Group B consisted of patients with chronic periodontitis, Group C of patients with rheumatoid arthritis and Group D had patients suffering from both arthritis and periodontitis. Periodontal parameters assessed were plaque index (PI), modified gingival index (GI) and probing depth (PD). Panoramic radiographs were taken to confirm the diagnosis of periodontitis. Rheumatoid arthritis was confirmed by the rheumatologists and seropositivity for rheumatoid factor (RF) was checked. Resistin levels were analysed in GCF collected from all the four groups and statistical analysis was done by using Pearson correlation coefficient. Results: The GCF of all the patients showed presence of resistin. The level of resistin was highest in Group D patients and least in Group A patients. On analysing the samples together positive co-relation was found between GCF resistin and PD, PI, GI and RF. Conclusion: Resistin levels are increased in both chronic periodontitis and rheumatoid arthritis. Therefore, the increased level of GCF resistin can be regarded as potential inflammatory marker for periodontitis and rheumatoid arthritis.
机译：背景：尽管发现牙周炎和类风湿关节炎具有相似的炎症机制，但相关研究文献较少。抵抗素是一种新型的脂肪因子，被认为是牙周炎和类风湿关节炎之间的常见纽带。本研究的目的是通过使用抵抗素作为有效的炎症标记物来加强牙周炎和类风湿关节炎之间的相互关系。资料和方法：选择本研究的一百名年龄大于30岁的男女患者，将其平均分为四组，每组25名患者。 A组由健康个体组成，B组由患有慢性牙周炎的患者组成，C组由类风湿性关节炎患者组成，D组由患有关节炎和牙周炎的患者组成。评估的牙周参数是菌斑指数（PI），改良牙龈指数（GI）和探查深度（PD）。拍摄全景X光片以确认牙周炎的诊断。风湿病学家确认了类风湿关节炎，并检查了类风湿因子（RF）的血清阳性。分析从所有四个组收集的GCF中的抵抗素水平，并使用Pearson相关系数进行统计分析。结果：所有患者的GCF均显示抵抗素存在。 D组患者抵抗素水平最高，A组患者最低。在分析样品时，发现GCF抵抗素与PD，PI，GI和RF之间存在正相关。结论：慢性牙周炎和类风湿关节炎的抵抗素水平均升高。因此，增加的GCF抵抗素水平可被视为牙周炎和类风湿关节炎的潜在炎症标志物。

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