...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Clinicopathological Study of Carcinoma of the Ampulla of Vater with Special Reference to MUC1, MUC2 and MUC5AC Expression EC17-EC20
【24h】

Clinicopathological Study of Carcinoma of the Ampulla of Vater with Special Reference to MUC1, MUC2 and MUC5AC Expression EC17-EC20

机译：特别是针对MUC1，MUC2和MUC5AC表达EC17-EC20的壶腹癌的临床病理研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: The ampulla of Vater consists of papilla, common channel, distal common bile duct and the distal main pancreatic duct. Ampullary carcinomas arise from two different types of mucosa, reflecting their broad histomorphological spectrum. Adenocarcinomas originating in the ampulla of Vater are classified as having either ?Intestinal? or ?pancreatobiliary? type of differentiation. Pancreatobiliary type has consistently shown a worse prognosis. Various types of mucins are distributed in normal tissues and gastrointestinal tumours. MUC1, MUC2 and MUC5AC are known to be the most important amongst all.Aim: To study clinicopathological features of different types of carcinoma of ampulla with MUC1, MUC2 and MUC5AC expression.Materials and Methods: We included 20 cases of ampullary adenocarcinoma in this study, diagnosed after radical surgery. The histopathological slides were reviewed and the tumours were classified into intestinal type, pancreatobilliary and other types. Representative block of tumours was subjected to immunohistochemical (IHC) study with MUC1, MUC2 and MUC5AC antibodies. Results were subsequently analysed.Results: Pancreaticobiliary type of ampullary carcinoma cases predominated (50%) over intestinal type (25%). Carcinomas of ?other types? included one case each of mucinous carcinoma, adenosquamous carcinoma and undifferentiated carcinoma and well differentiated neuroendocrine tumours. Pancreatobiliary type of carcinomas was associated with higher tumour stage and grade and lymph node metastasis. All the pancreatobiliary type expressed MUC1 and all intestinal type carcinomas expressed MUC2. MUC 5AC expression was seen predominantly in pancreatobiliary type of ampullary carcinomas.Conclusion: Mucin markers are associated with two different subtypes of ampullary carcinomas which have different prognosis. Immunohistochemical study of mucin expression can define the different types of carcinomas of ampulla of Vater with better objective criteria.
机译：简介：Vater壶腹由乳头，总通道，远端胆总管和远端主胰管组成。壶腹癌起源于两种不同类型的粘膜，反映了其广泛的组织形态学范围。起源于瓦特壶腹的腺癌被分类为具有“肠”或“肠”。或？分化类型。胰胆管型始终显示出较差的预后。各种类型的粘蛋白分布在正常组织和胃肠道肿瘤中。目的：以MUC1，MUC2和MUC5AC表达研究不同类型壶腹癌的临床病理特征。材料与方法：纳入20例壶腹腺癌。 ，经根治性手术诊断。回顾了组织病理学幻灯片，并将肿瘤分为肠型，胰源性和其他类型。用MUC1，MUC2和MUC5AC抗体对肿瘤的代表性阻滞进行免疫组织化学（IHC）研究。结果：结果：壶腹癌的胰腺胆管类型（50％）高于肠道类型（25％）。其他类型的癌？包括粘液癌，腺鳞癌和未分化癌各1例，以及分化良好的神经内分泌肿瘤。胰腺胆管癌类型与较高的肿瘤分期和分级以及淋巴结转移有关。所有的胰腺胆管型均表达MUC1，所有肠型癌均表达MUC2。结论：MUC 5AC在胰腺胆管型壶腹癌中表达。结论：粘蛋白标记物与壶腹癌的两种不同亚型具有不同的预后。粘蛋白表达的免疫组织化学研究可以更好的客观标准定义不同类型的Vater壶腹癌。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号