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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Factors Contributing Towards Poor Asthma Control in Patients on Regular Medication
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Factors Contributing Towards Poor Asthma Control in Patients on Regular Medication

机译：常规药物治疗患者哮喘控制不良的因素

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Introduction: In-spite of the availability of effective medications, it is observed that patients with bronchial asthma on treatment are poorly controlled. An objective evaluation of asthma control especially with respect to inflammation and the factors contributing towards poor control is crucial in obtaining relief of symptoms.Aim: 1) To measure the asthma control using modified Mini Asthma Quality Of Life Questionnaire (MAQOL) and sputum eosinophil count; 2) To identify the role of factors viz. age, duration of asthma, severity, compliance, technique of inhalation and knowledge of asthma action plan on asthma control.Materials and Methods: Total 50 asthmatic patients on regular medication were included in the study after obtaining written informed consent. The asthma-control was evaluated based on history, clinical symptoms, need for short-acting bronchodilators, FEVs1 and sputum eosinophil count with the help of modified MAQOL. A global score of <80% was considered as poor control. The proportion of patients under each factor, in poorly-controlled group (PC) was compared with the well-controlled group (WC). The results were analysed using descriptive statistics and unpaired student?s t-test. Results: Of the total, 33 (66%) patients were in PC category with a mean global asthma score of 58.46 ± 2.881 vs 85.2 ± 1.19 in the WC group (34%) (p<0.05). The mean age in PC was 41.41 ± 2.413 vs 29.00 ± 2.157(p<0.05) in the WC. The mean duration of asthma was 16.76 ± 2.761 in PC vs 7.882 ± 2.065 years in WC (p<0.05). The severity score was 7.265 ± 0.4434 in PC vs 6.706 ± 0.64 in WC. Eight patients in PC and six in WC were unaware of the treatment plan. One in PC group and three in WC were unaware of technique of inhalation. One in PC group and three in WC were non?compliant. Mean sputum eosinophil count was 7.441 ± 1.081 in PC vs 5.176 ± 1.201 in WC.Conclusion: MAQOL is useful in evaluating asthma-control. Sputum eosinophil count correlates with asthma-control. Duration of asthma, age and severity contributed significantly to the poor control of asthma. There is a need for an objective monitoring in asthma and the treatment strategies need to be modified accordingly
机译：简介：尽管可获得有效的药物，但观察到接受治疗的支气管哮喘患者的控制较差。客观评估哮喘控制，尤其是炎症和导致控制不佳的因素，对于缓解症状至关重要。目的：1）使用改良的微型哮喘生活质量调查表（MAQOL）和痰嗜酸性粒细胞计数来测量哮喘控制; 2）确定因素的作用即。年龄，哮喘病持续时间，严重程度，依从性，吸入技术以及哮喘控制计划的知识。材料与方法：总共50名接受常规药物治疗的哮喘患者在获得书面知情同意后被纳入研究。根据病史，临床症状，短效支气管扩张剂的需要，FEVs1和痰中嗜酸性粒细胞计数，在改良的MAQOL的帮助下评估哮喘的控制情况。 <80％的整体评分被认为是控制不良。将控制不佳组（PC）与控制良好组（WC）中每种因素下的患者比例进行比较。使用描述性统计数据和未配对的学生t检验对结果进行了分析。结果：总共33例（66％）患者属于PC类，全球平均哮喘评分为58.46±2.881，而WC组为85.2±1.19（34％％）（p <0.05）。 PC的平均年龄为41.41±2.413，而WC为29.00±2.157（p <0.05）。 PC的平均哮喘病程为16.76±2.761，而WC的平均哮喘病程为7.882±2.065年（p <0.05）。 PC的严重性评分为7.265±0.4434，而WC的严重度评分为6.706±0.64。 PC的8例患者和WC的6例患者不知道治疗计划。 PC组有1名，WC组有3名不知道吸入技术。 PC组中有1个，WC中有3个不符合标准。 PC的痰中嗜酸性粒细胞平均数为7.441±1.081，而WC为5.176±1.201。结论：MAQOL可用于评估哮喘控制。痰中嗜酸性粒细胞计数与哮喘控制相关。哮喘的持续时间，年龄和严重程度是导致哮喘控制不良的重要原因。需要对哮喘进行客观监测，并且治疗策略需要相应调整

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