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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Relationship between Neutrophil-to-Lymphocyte Ratio and Stress in Multiple Sclerosis Patients CC01-CC04
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Relationship between Neutrophil-to-Lymphocyte Ratio and Stress in Multiple Sclerosis Patients CC01-CC04

机译：多发性硬化症患者CC01-CC04中性粒细胞与淋巴细胞比例与压力的关系

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Introduction: Multiple Sclerosis (MS), a disease of autoimmunity and inflammation, is characterized by deterioration of the myelin sheath that protects the nerve fibers. The high levels of neutrophils in serum may be related to the chronic inflammation and caused by other triggers such as infections that have been associated with relapses in MS.Aim: To investigate the value of Neutrophil/Lymphocyte Ratio (NLR) as a possible marker and relationship with Depression, Anxiety and Stress (DAS) score in MS patients.Materials and Methods: A total of 60 MS patients and 60 age and sex matched healthy controls were recruited for the present study. We measured DAS score, NLR, calcium, phosphate, magnesium, chloride, alkaline phosphatase, albumin in serum levels in MS patients and in healthy controls.Results: The mean age was not significantly different in both case and control groups. The case and control groups were similar in terms of sex; however, the majority of the MS group was female. The NLR values of MS patients were significantly higher than those of the healthy controls (p=<0.001). The NLR values were also significantly (p<0.001) correlated with stress score.Conclusion: NLR could be considered as a quick, cheap, easily measurable and inflammatory marker for assessment of inflammation in MS patients. The role of NLR in MS must be explored further.
机译：简介：多发性硬化症（MS）是一种自身免疫性疾病和炎症，其特征是保护神经纤维的髓鞘变质。血清中高水平的中性粒细胞可能与慢性炎症有关，并可能是由其他诱因引起的，例如与MS复发相关的感染。目的：研究中性粒细胞/淋巴细胞比率（NLR）作为可能的标志物的价值，以及材料与方法：本研究共招募了60名MS患者以及60位年龄和性别相匹配的健康对照者。我们测量了MS患者和健康对照者血清中DAS评分，NLR，钙，磷酸盐，镁，氯化物，碱性磷酸酶，白蛋白的水平。结果：病例组和对照组的平均年龄没有显着差异。病例组和对照组的性别相似。但是，MS组的大多数是女性。 MS患者的NLR值显着高于健康对照者（p = <0.001）。 NLR值也与压力评分显着相关（p <0.001）。结论：NLR可被视为一种快速，廉价，易于测量和炎性标记，可用于评估MS患者的炎症。必须进一步探讨NLR在MS中的作用。

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