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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Evaluation of the Role of Dermatoglyphics, Oral Micronuclei and ABO Blood Grouping in Determining Type 2 Diabetes-A Multi-Parameter Approach
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Evaluation of the Role of Dermatoglyphics, Oral Micronuclei and ABO Blood Grouping in Determining Type 2 Diabetes-A Multi-Parameter Approach

机译：评价皮肤形态学，口腔微核和ABO血型在确定2型糖尿病中的作用-多参数方法

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Introduction: Diabetes mellitus type-2 affecting around 12% of Indian population is a multifactorial metabolic disease with several complications warranting high concern for effective prevention and control measures.Aim: To evaluate the role of dermatoglyphics, oral micronuclei and ABO blood grouping in determining Type 2 diabetes.Materials and Methods: A total of 44 diabetic patient and 45 age and sex matched healthy controls were selected. Palmar prints, oral cytosmears and blood samples were collected from both groups. Fingerprints and ATD angle were assessed from the palmar prints. Oral smears obtained were stained using Papanicolaou stain and assessed for micronuclei frequency. About 1 mL of blood sample obtained by venepuncture method was subjected to ABO blood grouping. Dermatoglyphic findings were expressed as Mean±SD. Independent sample t-test was used for comparison of ATD angle and oral micronuclei frequency in both groups. Chi-square test was used for testing the association of blood grouping to diabetes mellitus.Results: On fingerprint analysis, ulnar loops were found to be more in diabetics with reduced number of whorls. There was slight increase in arches as well except in left hand of diabetic females. Statistically significant results were obtained with ATD angle and oral micronuclei with diabetics having higher values. There was no significant association found between diabetes and blood groups.Conclusion: A panel of biomarkers which are simple, economical and rapid improves the screening surveillance of diabetes and act as an additional diagnostic tool. Micronuclei and ATD angle in the present study exhibited significant results and might be possible components of the panel. Mass screening of high risk individuals at community level can be achieved using a kit with the biomarkers. To validate the relation of blood groups to diabetes further evaluation over larger population is needed.
机译：简介：2型糖尿病是一种多因素代谢疾病，影响印度人口的12％，是一种多因素代谢疾病，值得高度关注，需要采取有效的预防和控制措施。目的：评估皮纹，口服微核和ABO血型在确定2型糖尿病中的作用2糖尿病。材料与方法：总共选择了44位糖尿病患者和45位年龄和性别相匹配的健康对照。两组均采集手掌印，口腔细胞涂片和血样。从手掌指纹评估指纹和ATD角度。使用巴氏染色对获得的口腔涂片染色，并评估微核频率。对通过静脉穿刺法获得的约1 mL血液样本进行ABO血型检查。皮肤文字的发现表示为平均值±标准差。使用独立样本t检验比较两组的ATD角和口腔微核频率。结果：在指纹分析中，发现尺骨loop在糖尿病患者中尤为明显，而螺纹的数量却减少了。除糖尿病女性的左手外，足弓也略有增加。使用ATD角和具有糖尿病值的糖尿病患者的口腔微核获得了统计学上显着的结果。结论：一组简单，经济，快速的生物标志物可以改善糖尿病的筛查监测，并作为一种附加的诊断工具。本研究中的微核和ATD角显示出显着结果，可能是面板的可能组成部分。可以使用带有生物标志物的试剂盒对社区中的高危个体进行大规模筛查。为了验证血型与糖尿病的关系，需要对更大的人群进行进一步评估。

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