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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Effect of Morphine, Codeine and Methadone on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study
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The Effect of Morphine, Codeine and Methadone on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study

机译：吗啡，可待因和美沙酮对大鼠正畸牙移动和骨组织组织学特征的影响：实验研究

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Orthodontic treatments are associated with pain. Opioids are commonly used to alleviate such pain which in turn can interfere with orthodontic treatment. Information about the effect of different types of opioids in Orthodontic Tooth Movement (OTM) is not substantial.Aim: To evaluate and compare the effect of three exogenous opioids (Morphine, Codeine and Methadone) on orthodontic tooth movement.Materials and Methods: Forty-eight male Wistar rats were randomly divided into four equal groups. Control group received a normal saline injection, and the three other groups received a daily injection of morphine, methadone, and codeine at the dose of 6,3,30 mg/kg respectively.A NiTi closed coil spring was used to tip the left upper first molar mesially. After twenty-one days of force delivery, the rats were sacrificed, and the rate of tooth movements was measured by a feeler gauge. Then, maxilla was dissected, fixed, and examined histologically. Kruskal-Wallis?s test was used for the comparison of OTM between four groups and for multiple comparisons analysis Mann-Whitney test was implemented.Results: The highest amount of tooth movement occurred in the control group (0.279 mm) which was significantly higher than the other three opioid groups (p 0.05). There was no statistically significant histological difference between the four groups (p>0.05).Conclusion: All three opioids used in this study reduced OTM regardless of differences in terms of duration of the effect.
机译：正畸治疗与疼痛有关。阿片类药物通常用于缓解这种疼痛，进而会干扰正畸治疗。 目的：评估和比较三种外源阿片类药物（吗啡，可待因和美沙酮）对正畸牙齿运动的影响。材料与方法：48只雄性Wistar大鼠随机分为四组。对照组注射生理盐水，其他三组分别每日注射吗啡，美沙酮和可待因，剂量分别为6,3,30 mg / kg。使用NiTi闭合螺旋弹簧使左上肢倾倒第一磨牙。传递力21天后，处死大鼠，并通过塞尺测量牙齿的运动速度。然后，将上颌骨解剖，固定并进行组织学检查。 b组结果：Kruskal-Wallis检验用于四组之间OTM的比较，并进行了多重比较分析。实施了Mann-Whitney检验。结果：对照组中最大的牙齿移动量（0.279 mm）是明显高于其他三个阿片类药物组（p 0.05）。四组之间的组织学差异无统计学意义（p> 0.05）。结论：本研究中使用的所有三种阿片类药物均降低了OTM，无论作用持续时间如何。

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