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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prevalence of Intestinal Parasitic Infections among Pulmonary Tuberculosis Patients in a Tertiary Care Hospital, Bhubaneswar, Odisha, India
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Prevalence of Intestinal Parasitic Infections among Pulmonary Tuberculosis Patients in a Tertiary Care Hospital, Bhubaneswar, Odisha, India

机译：印度奥里萨邦布巴内斯瓦尔三级医院的肺结核患者中肠道寄生虫感染的患病率

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In developing countries like India, Intestinal Parasitic Infections (IPIs) and Tuberculosis (TB) co-infection have been perceived to be high. The geographic distributions of helminths and TB overlap substantially. Parasitic infections affect the outcome of TB by shifting cell mediated immune response to humoral; while mycobacterium infection favours immune escape of helminths.Aim: To determine the prevalence of IPIs among pulmonary TB patients, to find out the type of intestinal parasitic infection in them and to analyse the association of risk factors with the prevalence of co-infection.Materials and Methods: A hospital based cross-sectional study was done among the 118 newly diagnosed pulmonary TB (PTB) patients attending the Pulmonary Medicine department of a tertiary care hospital, from 15th July-15th September 2016; after obtaining informed written consent. Demographic and clinical data was collected using structured questionnaire. Stool samples for direct microscopy and formalin-ether concentration technique was done for detection of intestinal parasites. Statistical analysis was performed using Epi Info software. Descriptive statistics, chi-square test were used; p-value of <0.05 was considered as statistically significant.Results: Of the 118 PTB patients enrolled, 71.18 % were sputum smear positive. The co-infection with intestinal parasites was 27.11%; 87.5% of the infections were due to helminths, of which 65.63% were due to hookworm (Ancylostoma duodenale and Necator americanus), 15.6% were due to Strongyloides stercoralis and 6.25% due to Ascaris lumbricoides. Co-infection was seen more in males (59.32%) and 1-15 years age group. Hookworm infections were higher in sputum smear positive cases than negative ones; this difference was also found to be statistically significant. Co-infection with E. histolytica was also found to have statistically significant difference between smear positive and negative cases.Conclusion: The study results reiterate the fact of a high prevalence of co-infection in this part of eastern India. There was a higher rate of co-infection among sputum positive TB cases. As co-infection is known to have a negative impact on the treatment outcome of these patients, healthcare providers should screen and treat all TB patients for intestinal parasitic co-infections in order to ensure good prognosis.
机译：在印度等发展中国家，人们普遍认为肠道寄生虫感染（IPIs）和结核病（TB）合并感染率很高。蠕虫和结核的地理分布基本重叠。寄生虫感染通过将细胞介导的免疫反应转移到体液而影响结核病的预后。目的：确定肺结核患者中IPI的患病率，找出其中的肠道寄生虫感染类型，并分析危险因素与共患病率之间的关系。 材料与方法：从2016年7月15日至9月15日，在三级医院肺科的118名新诊断的肺结核患者中进行了一项基于医院的横断面研究。在获得知情的书面同意后。使用结构化问卷收集人口和临床数据。粪便样本用于直接显微镜检查和福尔马林-醚浓缩技术用于检测肠道寄生虫。使用Epi Info软件进行统计分析。采用描述性统计，卡方检验; p值<0.05被认为具有统计学意义。结果：在118名PTB患者中，痰涂片阳性为71.18％。与肠道寄生虫的合并感染率为27.11％; 87.5％的感染归因于蠕虫，其中65.63％归因于钩虫（Ancylostoma duodenale和American Necator americanus），15.6％归因于硬壳纲圆线虫，而6.25％归因于A虫。男性（59.32％）和1-15岁年龄组的合并感染较多。痰涂片阳性病例中钩虫感染的发生率高于阴性病例。还发现这种差异具有统计学意义。在组织涂片阳性和阴性病例中，还发现与溶组织性大肠杆菌的合并感染在统计学上有显着差异。结论：研究结果重申了印度东部这一地区合并感染的普遍性。痰阳性结核病例中合并感染率更高。由于已知合并感染会对这些患者的治疗结果产生负面影响，因此医疗保健提供者应对所有结核病患者进行肠道寄生虫合并感染的筛查和治疗，以确保良好的预后。

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