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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effect of 1800-2100 MHz Electromagnetic Radiation on Learning-Memory and Hippocampal Morphology in Swiss Albino Mice
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Effect of 1800-2100 MHz Electromagnetic Radiation on Learning-Memory and Hippocampal Morphology in Swiss Albino Mice

机译：1800-2100 MHz电磁辐射对瑞士白化小鼠学习记忆和海马形态的影响

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With advancing technology the mobile phone with multiple features is used as a multipurpose device and attract people of all age groups. Increased usage of mobile phone raises the question of possible adverse effects on health.Aim: To assess the 1800-2100 MHz radiation effect on learning-memory and microscopic anatomy of hippocampal Cornu Ammonis (CA3) neurons in mice.Materials and Methods: A total of 18 albino mice were divided into 3 groups (6 Mice per group). Group-I: Control Group, Group-II: Exposed to Radio frequency-Electromagnetic radiation (RF-EMR) for 30 minutes/day for 3 months, Group-III: Exposed to RF-EMR for 60 minutes/day for 3 months. Followed by the exposure, learning memory was assessed by using Hebb-Williams maze in all the groups. The mice were then sacrificed, brains were dissected out and sections were taken at the level of hippocampus and then stained with Haematoxylin and Eosin for microscopy.The results were expressed in Mean±SD and analysed by using one-way (analysis of variance) ANOVA followed by LSD (Least Square Difference) test for paired wise data. The p-value<0.05 was considered as statistically significant.Results: The time taken by the animal to reach the target chamber was significantly increased in Group-III (exposed 60 minutes/day for 3 months), whereas group-II (exposed 30 minutes/day for 3 months) showed no significant changes when compared to Group-I (control group). Microscopic anatomy of hippocampal CA3 neurons in exposed group shows less number of pyramidal cells with darkened nuclei, cytoplasm was vacuolated and cells were scattered.Conclusion: Exposure to 1800-2100 MHz radiation leads to damage and decrease of neurons in hippocampal region, which alters the learning and memory.
机译：随着先进技术的发展，具有多种功能的手机被用作多功能设备，吸引了各个年龄段的人们。手机使用量的增加提出了可能对健康产生不利影响的问题。目的：评估1800-2100 MHz辐射对小鼠海马区Cornu Ammonis（CA3）神经元的学习记忆和显微解剖的影响。材料与方法：将18只白化病小鼠分为3组（每组6只小鼠）。第一组：对照组，第二组：暴露于射频电磁辐射（RF-EMR），每天30分钟，持续3个月，第三组：暴露于RF-EMR，每天60分钟，持续3个月。接触后，在所有组中使用Hebb-Williams迷宫评估学习记忆。然后处死小鼠，解剖大脑，在海马水平切开切片，然后用苏木精和曙红染色进行显微镜检查。结果以Mean±SD表示，并使用单向（方差分析）ANOVA进行分析然后通过LSD（最小二乘差）检验成对的明智数据。 p值<0.05被认为具有统计学意义。结果：在III组中，动物到达目标小室所需的时间显着增加（每天暴露60分钟，持续3个月），而II组（每天暴露30分钟，持续3个月）与I组（对照组）相比无明显变化。暴露组海马CA3神经元的显微解剖显示，锥体细胞数量减少，核变暗，胞浆空泡，细胞散落。结论：暴露于1800-2100 MHz辐射会导致海马区神经元的损伤和减少，这会改变学习和记忆。

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