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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role of Gamma Glutamyl Transferase in the Diagnosis of Metabolic Syndrome in Patients with Hypothyroidism
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Role of Gamma Glutamyl Transferase in the Diagnosis of Metabolic Syndrome in Patients with Hypothyroidism

机译：γ-谷氨酰转移酶在甲状腺功能减退症患者代谢综合征的诊断中的作用

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Hypothyroidism is the most prevalent thyroid disorder in India that affects one in ten adults. Gamma Glutamyl Transferase (GGT) is an ectopic enzyme associated with oxidative stress in various diseased conditions. Prior research suggests that increased levels of GGT are associated with Metabolic Syndrome (MetS) in hypothyroidism.Aim: To study the prevalence of MetS in patients with hypothyroidism and to correlate serum GGT levels with the components of MetS.Materials and Methods: The case-control study was conducted on 62 clinically diagnosed hypothyroidism patients (cases) and 63 clinically proven healthy subjects (controls). All these subjects were screened for metabolic syndrome based on the NCEP ATP ??? (National Cholesterol Education Programme Adult Treatment Panel III) guidelines. Waist circumference, blood pressure, serum Fasting Blood Sugar (FBS), Urea, Creatinine, T3, T4, Thyroid Stimulating Hormone (TSH), Total Cholesterol (TC), Triglycerides (TG), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C) and GGT were measured. Data was expressed as mean±SD and analysed using Independent Student t-test. The p-value <0.05 was considered as statistically significant.Results: Waist circumference, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), FBS, TC, Triglycerides TG, LDL-C, GGT and TSH were significantly increased in hypothyroid cases when compared to the controls. HDL-C was significantly decreased in hypothyroid cases. Significant positive correlation was observed between GGT and TSH (r=0.57, p=0.004) in hypothyroid cases with MetS. Significant inverse correlation was observed between GGT and HDL-C (r=-0.25, p=0.04) in hypothyroid cases.Conclusion: In this study, 38% of hypothyroid patients had MetS. Serum GGT is found to be elevated in hypothyroid cases and associated with components of MetS. Hence GGT can be used as an additional diagnostic marker to assess the MetS in hypothyroidism.
机译：甲状腺功能减退是印度最普遍的甲状腺疾病，影响十分之一的成年人。 γ谷氨酰胺基转移酶（GGT）是与多种疾病条件下的氧化应激相关的异位酶。先前的研究表明，甲状腺功能减退症中代谢综合征（MetS）与GGT水平升高有关。目的：研究甲状腺功能减退症患者中MetS的患病率，并将血清GGT水平与MetS的成分相关联。材料方法：对62名临床诊断为甲状腺功能减退症的患者（病例）和63名经临床证实的健康受试者（对照）进行了病例对照研究。根据NCEP ATP对所有这些受试者进行了代谢综合征的筛查。 （国家胆固醇教育计划成人治疗小组III）指南。腰围，血压，空腹血糖（FBS），尿素，肌酐，T3，T4，甲状腺刺激激素（TSH），总胆固醇（TC），甘油三酸酯（TG），高密度脂蛋白胆固醇（HDL-C），测量低密度脂蛋白胆固醇（LDL-C）和GGT。数据表示为平均值±SD，并使用独立学生t检验进行分析。 p值<0.05被认为具有统计学意义。结果：腰围，收缩压（SBP），舒张压（DBP），FBS，TC，甘油三酸酯TG，LDL-C，GGT和TSH显着与对照组相比，甲状腺功能减退的病例增加。在甲状腺功能减退的病例中，HDL-C显着降低。在甲状腺功能减退的MetS患者中，GGT和TSH之间存在显着正相关（r = 0.57，p = 0.004）。在甲状腺功能减退的病例中，GGT和HDL-C之间存在显着的负相关性（r = -0.25，p = 0.04）。结论：在这项研究中，甲状腺功能减退症患者中有38％患有MetS。发现甲状腺功能减退症患者的血清GGT升高，并且与MetS的成分有关。因此，GGT可以用作评估甲状腺功能减退症中MetS的附加诊断指标。

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