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首页> 外文期刊>Journal of bacteriology >Catabolism of L-tyrosine by the homoprotocatechuate pathway in gram-positive bacteria.
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Catabolism of L-tyrosine by the homoprotocatechuate pathway in gram-positive bacteria.

机译：L-酪氨酸在克氏阳性细菌中通过高原儿茶酸途径的分解代谢。

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摘要

A metabolic pathway for L-tyrosine catabolism involves 3,4-dihydroxyphenylacetic acid (homoprotocatechuic acid) as substrate for fission of the benzene nucleus. Cell extracts of an organism tentatively identified as a Micrococcus possessed the enzymes required for degrading homoprotocatechuate to succinate and pyruvate, and stoichiometry was established for several of these reactions. When the required coenzymes were added, cell extracts degraded L-tyrosine to the ring-fission product of homoprotocatechuate 2,3-dioxygenase and also converted 4-hydroxyphenylpyruvic acid into 4-hydroxyphenylacetic acid. This compound, in turn, gave stoichiometric amounts of the ring-fission product of homoprotocatechuate by the action of a nicotinamide adenine dinucleotide phosphate-dependent 3-hydroxylase coupled with homoprotocatechuate 2,3-dioxygenase. Evidence is presented that this route for L-tyrosine catabolism is taken by five other gram-positive strains, including Micrococcus lysodeikticus and a species of Bacillus. Five other gram-positive bacteria from other genera employed the alternative homogentisate pathway.
机译：L-酪氨酸分解代谢的代谢途径涉及3,4-二羟基苯基乙酸（同原儿茶酸）作为苯核裂变的底物。暂时被鉴定为微球菌的生物的细胞提取物具有将原儿茶酸降解为琥珀酸和丙酮酸所需的酶，并为其中的几种反应建立了化学计量。当添加所需的辅酶时，细胞提取物将降解的L-酪氨酸降解为高原儿茶酸2,3-二加氧酶的环裂变产物，并将4-羟基苯基丙酮酸转化为4-羟基苯基乙酸。该化合物继而通过烟酰胺腺嘌呤二核苷酸磷酸依赖性3-羟化酶与高纯儿茶酸2，3-二加氧酶偶联而产生化学计量的高纯儿茶酸的环裂变产物。证据表明，这种L-酪氨酸分解代谢途径是由其他5种革兰氏阳性菌株采取的，包括lysodeikticus微球菌和一种芽孢杆菌。来自其他属的其他五种革兰氏阳性细菌采用了替代性纯黑藻酸盐途径。

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