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首页> 外文期刊>Journal of bacteriology >Regulation of Glutamine Synthetase VI. Interactions of Inhibitors for Bacillus licheniformis Glutamine Synthetase
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Regulation of Glutamine Synthetase VI. Interactions of Inhibitors for Bacillus licheniformis Glutamine Synthetase

机译：谷氨酰胺合成酶的调节VI。地衣芽孢杆菌谷氨酰胺合成酶抑制剂的相互作用

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摘要

The relationships of five feedback inhibitors for the Bacillus licheniformis glutamine synthetase were investigated. The inhibitors were distinguishable by differences in their competitive relationship for the substrates of the enzyme. Mixtures of l-glutamine and adenosine-5′-monophosphate (AMP) or histidine and AMP caused synergistic inhibition of glutamine synthesis. Histidine, alanine, and glycine acted antagonistically toward the l-glutamine inhibition. Alanine acted antagonistically toward the glycine and histidine inhibitions. Independence of inhibitory action was observed with the other pairs of effectors. Possible mechanisms by which the inhibitors may interact to control glutamine synthesis are discussed. The low rate of catalysis of the glutamyl transfer reaction by the B. licheniformis glutamine synthetase can be attributed to the fact that l-glutamine serves both as a substrate and an inhibitor for the enzyme. Effectors which act antagonistically toward the l-glutamine inhibition stimulated glutamotransferase activity. The stimulation was not observed when d-glutamine was used as substrate for the glutamyl transfer reaction.
机译：研究了地衣芽孢杆菌谷氨酰胺合成酶的五种反馈抑制剂之间的关系。抑制剂通过与酶底物的竞争关系不同而可区分。 l-谷氨酰胺和5'-单磷酸腺苷（AMP）或组氨酸和AMP的混合物可协同抑制谷氨酰胺合成。组氨酸，丙氨酸和甘氨酸对l-谷氨酰胺抑制具有拮抗作用。丙氨酸对甘氨酸和组氨酸的抑制具有拮抗作用。观察到其他对效应子的抑制作用独立性。讨论了抑制剂可能相互作用以控制谷氨酰胺合成的可能机制。 B催化的谷氨酰胺转移反应速率低。地衣形谷氨酰胺合成酶可归因于1-谷氨酰胺既是该酶的底物又是抑制剂。对1-谷氨酰胺抑制有拮抗作用的效应子刺激了谷氨酰胺转移酶活性。当将d-谷氨酰胺用作谷氨酰转移反应的底物时，未观察到刺激。

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