Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli.

E T Palva; T R Hirst; S J Hardy; J Holmgren; L Randall

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Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli.

机译：大肠杆菌中不耐热肠毒素B亚基的前体的合成。

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Escherichia coli K-12 minicells were employed to investigate the biosynthesis of plasmid-encoded, heat-labile enterotoxin of E. coli. Two polypeptide species related to the B subunit of the toxin were expressed in the minicells. One of these polypeptides (molecular weight, 11,500) was immunoprecipitated by antiserum to cholera toxin. Because the B subunits of heat-labile enterotoxin and cholera toxin have common antigenic sites, we concluded that this species was the mature B subunit. The larger polypeptide (molecular weight, 13,000) is likely to be a precursor of the B subunit because it could be chased into the mature form. This conversion was inhibited by compounds which dissipate proton motive force, suggesting that processing requires energy.

机译：大肠杆菌K-12小细胞用于研究质粒编码的热不稳定肠毒素的生物合成。在小细胞中表达了与毒素的B亚基有关的两种多肽。这些多肽之一（分子量11,500）通过抗血清对霍乱毒素进行免疫沉淀。由于热不稳定肠毒素和霍乱毒素的B亚基具有共同的抗原位点，因此我们得出结论，该物种是成熟的B亚基。较大的多肽（分子量为13,000）很可能是B亚基的前体，因为它可能被追逐为成熟形式。耗散质子原动力的化合物抑制了这种转化，表明加工需要能量。

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《Journal of bacteriology》 |1981年第1期|共6页
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E T Palva; T R Hirst; S J Hardy; J Holmgren; L Randall;
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1. In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B₅) from Escherichia coli. [J] . Liang S. A., Hosur K. B., Nawar H. F., Vaccine . 2009,第32期

机译：大肠杆菌中IIb型不耐热肠毒素（LT-IIb-B _{5 ）B亚基的体内和体外佐剂活性。}
2. Sequence analysis of the heat-labile enterotoxin subunit B gene originating in human enterotoxigenic Escherichia coli. [J] . T Yamamoto, T Tamura, M Ryoji, Journal of bacteriology . 1982,第1期

机译：源自人肠毒素性大肠杆菌的不耐热肠毒素亚基B基因的序列分析。
3. Plasmids coding for colonization factor antigens I and II, heat-labile enterotoxin, and heat-stable enterotoxin A2 in Escherichia coli. [J] . P Echeverria, J Seriwatana, D N Taylor, Infection and immunity . 1986,第2期

机译：编码大肠杆菌中定居因子抗原I和II，不耐热肠毒素和热稳定肠毒素A2的质粒。
4. Nanoparticulated Heat-Stable(STa)and Heat-Labile B Subunit(LTB)Recombinant Toxin Improves Vaccine Protection Against Enterotoxigenic Escherichia coli Challenge in Mouse [C] . Deng Guangcun, Zeng Jin, Jian Minjie, 16th International congress on animal hygiene : animal hygiene, health and welfare as corner stones of sustainable animal production . 2013

机译：纳米颗粒热稳定（STa）和不耐热B亚基（LTB）重组毒素可提高疫苗抵抗小鼠肠毒素性大肠杆菌的挑战
5. The role of heat-labile enterotoxin in the colonization of the small intestine by enterotoxigenic Escherichia coli. [D] . Santiago-Mateo, Kristina B. 2009

机译：不耐热肠毒素在产肠毒素的大肠杆菌在小肠定植中的作用。
6. Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli. [O] . E T Palva, T R Hirst, S J Hardy, 1981

机译：大肠杆菌中不耐热肠毒素B亚基前体的合成。
7. Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli [O] . E T Palva, T R Hirst, S J Hardy, 1981

机译：对大肠杆菌中热不稳定肠毒素B亚基的前体的合成
8. Plasmids Coding for Colonization Factor Antigens I and II, Heat-Labile Enterotoxin, and Heat-Stable Enterotoxin A2 in Escherichia coli. [R] . Echeverria, P., Seriwatana, J., Taylor, D. N., 1986

机译：质粒编码在大肠杆菌中的定殖因子抗原I和II，热不稳定肠毒素和热稳定肠毒素a2。

Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli.

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