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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparative Evaluation of Serum Malondialdehyde (MDA) Level in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma
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Comparative Evaluation of Serum Malondialdehyde (MDA) Level in Oral Submucous Fibrosis and Oral Squamous Cell Carcinoma

机译：口腔黏膜下纤维化和口腔鳞状细胞癌中血清丙二醛（MDA）水平的比较评估

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摘要

Lipid peroxidation, which is induced by reactive oxygen species, is involved in the pathogenesis of malignancy. This lipid peroxidation levels are indicated by Malondialdehyde (MDA), which is the most frequently, used biomarker for the detection of oxidative changes.Aim: Comparative evaluation of serum MDA level in Oral Submucous Fibrosis (OSMF) and Oral Squamous Cell Carcinoma (OSCC) patients and comparison of their serum MDA levels with healthy controls.Materials and Methods: The study included 150 patients comprising 50 apparently healthy controls without any tobacco chewing habits, 50 clinically diagnosed patients with OSMF which were also subgrouped according to Interincisal Opening (IIO) and 50 clinically diagnosed patients with OSCC, they were also subgrouped according to site, size and histopathological differentiation. Blood samples were obtained; serum was separated and evaluated for MDA levels, by using principle of spectrophotometry at 532 nm absorbance. Statistical analysis were conducted using independent t-test and one-wayanova test. Statistical package for social science (SPSS 16) was used for the analysis.Results: The mean serum malondialdehyde level in the control group was found to be 10.50 nmol/mL, whereas it was 25.87 nmol/mL and 57.00 nmol/mL in OSMF and OSCC, respectively. Different grades of OSMF patients according to IIO showed p<0.05, which was statistically significant. Among the subgroups of OSCC patients with respect to site and histopathological differentiation the results were not significant whereas there was statistically significant increase in MDA levels with increase in primary tumour size.Conclusion: The increased level of MDA reflects the extent of lipid peroxidation and is considered to be mutagenic as well as carcinogenic and can also modulate the expression of genes related to tumour promotion.
机译：活性氧引起的脂质过氧化作用参与了恶性肿瘤的发病机理。该脂质过氧化水平由丙二醛（MDA）指示，丙二醛是检测氧化变化最常用的生物标志物。目的：比较评估口腔粘膜下纤维化（OSMF）和口腔鳞状细胞癌中血清MDA的水平。 （OSCC）患者并将其血清MDA水平与健康对照进行比较。材料与方法：该研究包括150名患者，其中包括50名明显健康的对照，没有任何咀嚼烟草的习惯; 50名经临床诊断的OSMF患者也按照以下方法分组切开术（IIO）和50例临床诊断为OSCC的患者，也根据部位，大小和组织病理学差异进行分组。获得血样;通过使用分光光度法在532nm吸光度的原理分离血清并评估MDA水平。使用独立的t检验和单向新星检验进行统计分析。结果使用了社会科学统计软件包（SPSS 16）。结果：对照组的平均丙二醛水平为10.50 nmol / mL，而分别为25.87 nmol / mL和57.00 nmol / mL。分别在OSMF和OSCC中。根据IIO，不同等级的OSMF患者的p <0.05，具有统计学意义。在原位和组织病理学分化方面的OSCC患者亚组中，结果并不显着，而随着原发肿瘤大小的增加，MDA水平也有统计学上的显着提高。结论：MDA的水平升高反映了脂质过氧化的程度并且被认为具有致突变性和致癌性，并且还可以调节与肿瘤促进相关的基因的表达。

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