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首页> 外文期刊>Journal of bacteriology >Some Biological Effects of Carbamoyloxyurea, an Oxidation Product of Hydroxyurea
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Some Biological Effects of Carbamoyloxyurea, an Oxidation Product of Hydroxyurea

机译:氨基脲氧化产物氨基甲酰氧基脲的某些生物效应

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摘要

Carbamoyloxyurea, an oxidation product of hydroxyurea, is bactericidal for Escherichia coli. Drug-induced killing is independent of cellular metabolism; ribonucleic acid and protein syntheses are the processes most affected, and the lethal action is accompanied by degradation of cellular deoxyribonucleic acid. In all of these effects the drug differs from hydroxyurea, a primarily bacteriostatic agent that inhibits deoxyribonucleic acid synthesis, whose lethal action ultimately depends on cellular activity.
机译:氨基甲酰氧基脲是羟基脲的一种氧化产物,可对大肠杆菌进行杀菌。药物诱导的杀伤与细胞代谢无关。核糖核酸和蛋白质的合成是受影响最严重的过程,并且致命作用伴随着细胞脱氧核糖核酸的降解。在所有这些作用中,该药物不同于羟基脲,后者是一种主要的抑菌剂,可抑制脱氧核糖核酸的合成,其致命作用最终取决于细胞活性。

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