Attachment of pneumococcal autolysin to wall teichoic acids, an essential step in enzymatic wall degradation.

S Giudicelli; A Tomasz

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Attachment of pneumococcal autolysin to wall teichoic acids, an essential step in enzymatic wall degradation.

机译：肺炎球菌自溶素与壁壁chochochoic酸的附着，这是酶壁降解的重要步骤。

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High concentrations of choline and phosphorylcholine blocked the adsorption of pneumococcal autolytic enzyme to homologous cell walls and inhibited enzymatic cell wall hydrolysis in a noncompetitive manner. Enzyme adsorption had an absolute requirement for the presence of choline residues in the wall teichoic acid. Other amino alcohols and derivatives such as ethanolamine, monomethylaminoethanolamine , and phosphorylethanolamine had no effect on enzyme adsorption or hydrolytic activity. It is proposed that enzymatic hydrolysis of cell walls requires prior adsorption of enzyme molecules to the insoluble wall substrate and that cholin residues of the wall teichoic acid have the role of adsorption ligands in this process.

机译：高浓度的胆碱和磷酸胆碱会阻止肺炎球菌自溶酶吸附到同源细胞壁上，并以非竞争性方式抑制酶细胞壁的水解。酶吸附绝对需要壁壁胆酸中存在胆碱残基。其他氨基醇及其衍生物，例如乙醇胺，一甲基氨基乙醇胺和磷酰基乙醇胺，对酶的吸附或水解活性没有影响。有人提出，细胞壁的酶促水解需要事先将酶分子吸附到不溶性壁基质上，并且壁邻苯二甲酸的胆碱残基在此过程中具有吸附配体的作用。

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《Journal of bacteriology》 |1984年第3期|共3页
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S Giudicelli; A Tomasz;
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中图分类微生物学;
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2. In Vitro Reconstitution of Two Essential Steps in Wall Teichoic Acid Biosynthesis [J] . Cynthia Ginsberg, Yu-Hui Zhang, Yanqiu Yuan, ACS Chemical Biology . 2006,第1期

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3. Wall Teichoic Acids Are Involved in the Medium-Induced Loss of Function of the Autolysin CD11 against Clostridium difficile [J] . Xia Wu, Elena E. Paskaleva, Krunal K. Mehta, Scientific reports. . 2016,第1期

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5. Role of wall teichoic acid L- rhamnosylation in Listeria monocytogenes resistance to antimicrobial peptides and surface protein anchoring. [D] . Carvalho, Filipe Freitas Coelho Henriques de. 2016

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6. Attachment of pneumococcal autolysin to wall teichoic acids an essential step in enzymatic wall degradation. [O] . S Giudicelli, A Tomasz 1984

机译：肺炎球菌自溶素与壁壁chochochoic酸的附着这是酶壁降解的重要步骤。
7. Attachment of pneumococcal autolysin to wall teichoic acids, an essential step in enzymatic wall degradation [O] . S Giudicelli, A Tomasz 1984

机译：肺炎球菌亲羟乙烯对壁噻克酸的附着，酶壁劣化的基本步骤
8. The Effect of Nozzle Geometry on the Total Pressure Distribution in Wall Jets on a Circular Attachment Wall and on Jet-Wall Edge Interaction [R] . Owczarek, J. A., Rockwell, D. O., Cha, Y. S. 1970

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Attachment of pneumococcal autolysin to wall teichoic acids, an essential step in enzymatic wall degradation.

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