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首页> 外文期刊>Journal of bacteriology >Identification and characterization of a relA-dependent starvation-inducible locus (sin) in Salmonella typhimurium.
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Identification and characterization of a relA-dependent starvation-inducible locus (sin) in Salmonella typhimurium.

机译：鼠伤寒沙门氏菌中依赖relA的饥饿诱导型基因座（罪）的鉴定和表征。

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摘要

By use of Mu cts d1(Ap lac) phage, a strain of Salmonella typhimurium was isolated containing a Mu d insertion in a locus (sinA) which is induced during nicotinate, thiamine, purine, amino acid, phosphate, and carbon starvation conditions. Depending on the starvation condition, a 2- to 10-fold increase in beta-galactosidase activity was demonstrated. The sinA locus, which mapped at 32 U, became induced after a decline in growth rate due to starvation. The introduction of relA into the sinA-lac strain prevented induction by nicotinate starvation and partially prevented induction by phosphate starvation. The data suggest that sinA responds to changes in growth rate due to various nutrient starvation conditions and probably responds in part to changes in guanosine tetraphosphate levels.
机译：通过使用Mu cts d1（Ap lac）噬菌体，分离出鼠伤寒沙门氏菌菌株，其中在基因座（sinA）中包含Mu d插入，该插入在烟酸，硫胺素，嘌呤，氨基酸，磷酸盐和碳饥饿条件下诱导。根据饥饿状况，证明了β-半乳糖苷酶活性提高了2到10倍。由于饥饿导致生长速率下降后，定位在32 U处的sinA基因座被诱导。将relA引入sinA-lac菌株可防止烟酸饥饿诱导，并部分防止磷酸盐饥饿诱导。数据表明，sinA对各种营养不足条件引起的生长速率变化做出响应，并且可能部分对鸟苷四磷酸水平的变化做出响应。

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