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首页> 外文期刊>Journal of bacteriology >Effect of gyrB-mediated changes in chromosome structure on killing of Escherichia coli by ultraviolet light: experiments with strains differing in deoxyribonucleic acid repair capacity.
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Effect of gyrB-mediated changes in chromosome structure on killing of Escherichia coli by ultraviolet light: experiments with strains differing in deoxyribonucleic acid repair capacity.

机译:gyrB介导的染色体结构变化对紫外线杀死大肠杆菌的影响:用脱氧核糖核酸修复能力不同的菌株进行的实验。

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摘要

Mutations at the gyrB locus were found to decrease the degree of supercoiling of the Escherichia coli chromosome. The effect of a gyrB mutation on the repair of ultraviolet-induced deoxyribonucleic acid damage was studied by following the killing of strains of E. coli K-12 proficient and deficient in deoxyribonucleic acid repair. The effectiveness of both excision and postreplication types of deoxyribonucleic acid repair was found to be altered by this mutation, the former being apparently enhanced and the latter impaired.
机译:发现在gyrB基因座处的突变降低了大肠杆菌染色体的超螺旋程度。通过杀死熟练和缺乏脱氧核糖核酸修复能力的大肠杆菌K-12菌株,研究了gyrB突变对紫外线诱导的脱氧核糖核酸损伤修复的影响。发现该突变改变了切除和复制后类型的脱氧核糖核酸修复的有效性,前者明显增强而后者受损。

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