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首页> 外文期刊>Journal of bacteriology >Isolation and mapping of Escherichia coli mutations conferring resistance to division inhibition protein DicB.
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Isolation and mapping of Escherichia coli mutations conferring resistance to division inhibition protein DicB.

机译：赋予对分裂抑制蛋白DicB的抗性的大肠杆菌突变的分离和定位。

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摘要

Temperature-sensitive dicA mutants of Escherichia coli, dicA1(Ts), are blocked for cell division, owing to derepressed expression of a division inhibition gene, dicB. We isolated mutants which survived a high temperature in the dicA1 background and which survived induced expression of dicB carried by a high-copy-number plasmid. Most of the mutations conferred very slow growth on the cells. Two were mapped to the 90-min cluster of genes involved in translation and transcription, in or very close to gene rpoB. The majority of the other mutations were found to cause variable degrees of minicell formation and to map within or very close to the minB locus. Contrary to these mutations, the canonical min-1 mutation did not confer resistance to DicB.
机译：大肠杆菌的温度敏感dicA突变体dicA1（Ts）由于分裂抑制基因dicB的表达降低而被阻止细胞分裂。我们分离了在dicA1背景下在高温下存活且在高拷贝数质粒携带的dicB诱导表达下存活的突变体。大多数突变赋予细胞非常缓慢的生长。在rpoB基因中或非常接近的基因中，有两个被定位到参与翻译和转录的90分钟基因簇中。发现其他大多数突变会导致不同程度的小细胞形成，并定位在minB基因座内或非常接近minB基因座。与这些突变相反，规范的min-1突变并未赋予对DicB的抗性。

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