A novel mutation, cog, which results in production of a new porin protein (OmpG) of Escherichia coli K-12.

R Misra; S A Benson

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A novel mutation, cog, which results in production of a new porin protein (OmpG) of Escherichia coli K-12.

机译：一个新的突变cog，导致产生了大肠杆菌K-12的新孔蛋白（OmpG）。

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A mutant of Escherichia coli K-12 which produces a new outer membrane protein, OmpG, was isolated and genetically and biochemically characterized. The presence of OmpG allows growth on maltodextrins in the absence of the LamB maltoporin. The data obtained from in vivo growth and uptake experiments suggested that the presence of the OmpG protein results in an increase in outer membrane permeability for small hydrophilic compounds. In light of these findings, we suggest that OmpG is a porinlike protein. The mutation which results in the expression of OmpG has been termed cog (for control of OmpG) and mapped to 29 min on the E. coli chromosome. Diploid analysis shows that the mutant cog-192 allele is recessive for both the Dex+ and OmpG+ phenotypes. We propose that the cog mutation destroys a negative regulatory function and therefore derepresses ompG expression.

机译：分离出产生新的外膜蛋白OmpG的大肠杆菌K-12突变体，并进行了遗传和生物化学表征。 OmpG的存在允许在缺少LamB麦芽糖蛋白的情况下在麦芽糊精上生长。从体内生长和吸收实验获得的数据表明，OmpG蛋白的存在导致小亲水化合物的外膜通透性增加。根据这些发现，我们建议OmpG是一种孔蛋白样蛋白。导致OmpG表达的突变被称为cog（用于控制OmpG），并定位到大肠杆菌染色体上29分钟。二倍体分析显示，突变的cog-192等位基因对于Dex +和OmpG +表型都是隐性的。我们建议cog突变破坏负调节功能，因此降低ompG表达。

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《Journal of bacteriology》 |1989年第8期|共7页
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R Misra; S A Benson;
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中图分类微生物学;
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1. Identification of OmpR: a positive regulatory protein controlling expression of the major outer membrane matrix porin proteins of Escherichia coli K-12. [J] . R K Taylor, M N Hall, L Enquist, Journal of bacteriology . 1981,第1期

机译：OmpR的鉴定：一种阳性调节蛋白，可控制大肠杆菌K-12主要外膜基质孔蛋白的表达。
2. Biochemistry and Regulation of a NovelEscherichia coli K-12 Porin Protein, OmpG, Which Produces Unusually Large Channels [J] . Daniel A. Fajardo, Joyce Cheung, Chikako Ito, Journal of bacteriology . 1998,第17期

机译：产生异常大通道的新型大肠杆菌K-12孔蛋白OmpG的生物化学和调控
3. Genetic identification of the pore domain of the OmpC porin of Escherichia coli K-12. [J] . R Misra, S A Benson Journal of bacteriology . 1988,第8期

机译：大肠杆菌K-12 OmpC孔蛋白孔结构域的遗传鉴定。
4. Siderophore Receptor and Porin Protein Technology for Control of Salmonella and Escherichia coli 0157:H7 in Cattle [C] . E.T. Stevens, D.U. Thomson Annual Conference of American Association of Bovine Practitioners . 2005

机译：西参受体和孔素蛋白质技术控制沙门氏菌和大肠杆菌0157：H7在牛中
5. Functional studies of acyl carrier protein and the phosphopantetheinyl transferase AcpT in Escherichia coli K-12. [D] . Delay, Nicholas R. 2007

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6. A novel mutation cog which results in production of a new porin protein (OmpG) of Escherichia coli K-12. [O] . R Misra, S A Benson 1989

机译：一个新的突变cog导致产生了大肠杆菌K-12的新孔蛋白（OmpG）。
7. A novel mutation, cog, which results in production of a new porin protein (OmpG) of Escherichia coli K-12. [O] . Misra, R, Benson, S A 1989

机译：一个新的突变cog，导致产生了大肠杆菌K-12的新孔蛋白（OmpG）。
8. Mutations in the Histone-like Nucleoid Structuring Regulatory Gene (hns) Decrease the Adherence of Shiga Toxin-producing Escherichia coli 091:H21 Strain B2F1 to Human Colonic Epithelial Cells and Increase the Production of Hemolysin. [R] . Scott, M. E. 1999

机译：组蛋白样核结构调节基因（hns）中的突变降低产生志贺毒素的大肠杆菌091：H21菌株B2F1对人结肠上皮细胞的粘附性并增加溶血素的产生。

A novel mutation, cog, which results in production of a new porin protein (OmpG) of Escherichia coli K-12.

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