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首页> 外文期刊>Journal of bacteriology >The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis.
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The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis.

机译：能力转录因子合成的调节构成枯草芽孢杆菌能力调节中的关键控制点。

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摘要

comK, which encodes the competence transcription factor, is itself transcriptionally activated at the transition from exponential growth to stationary phase in Bacillus subtilis. MecA, a negative regulator of competence, also inhibits comK transcription when overexpressed, and a mecA null mutation results in comK overexpression. Although null mutations in mecA, as well as in another gene, mecB, are known to bypass the requirements for nearly all of the competence regulatory genes, the comK requirement is not suppressed by mecA inactivation. Various competence regulatory genes (comA, srfA, degU, abrB, sin, and spo0A) are shown to be required for the expression of comK. srfA transcription is shown to occur equally in cells destined for competence and those destined not to become competent. In contrast, comK transcription is restricted to the presumptive competent cells. These and other results are combined to describe a regulatory pathway for competence.
机译：编码能力转录因子的comK本身在枯草芽孢杆菌从指数生长到固定相的转变中被转录激活。 MecA，一种能力的负调节剂，在过表达时也抑制comK转录，而mecA null突变导致comK过表达。尽管已知mecA以及另一个基因mecB中的无效突变绕过了几乎所有功能调节基因的需求，但comK需求并未因mecA失活而受到抑制。各种能力调节基因（comA，srfA，degU，abrB，sin和spo0A）被证明是comK表达所必需的。显示srfA转录在注定要具有竞争能力的细胞和注定不具有能力的细胞中均等发生。相反，comK转录仅限于推测的感受态细胞。这些结果和其他结果结合起来描述了能力的调节途径。

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