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首页> 外文期刊>Journal of bacteriology >Conservation and variation of nucleotide sequences within related bacterial genomes: enterobacteria.
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Conservation and variation of nucleotide sequences within related bacterial genomes: enterobacteria.

机译：相关细菌基因组内核苷酸序列的保守和变异：肠杆菌。

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We have assessed the degree of relatedness of several portions of the Escherichia coli genome to the corresponding portions of the genomes of representative enteric bacteria, using the Southern transfer and hybridization technique (E. Southern, J. Mol. Biol. 98:503-517, 1975). The degree of relatedness varied among the regions examined. Judging both by the relative amounts of deoxyribonucleic acid in the various enteric genomes that are highly homologous and by the conservation of positions of restriction enzyme cleavage sites in these regions, the enteric genomes have diverged to greater extents in some parts of the genomes than in others. Portions of the genomes (including the tnaA and thyA genes, the trp operon, and one other unassigned segment) appear to have evolved in concert with the genome as a whole. By contrast, the lacZ gene and portions of the genome that are homologous to phage lambda vary more widely, perhaps reflecting a separate evolutionary origin for these segments of deoxyribonucleic acid.
机译：我们已经使用Southern转移和杂交技术（E. Southern，J. Mol。Biol。98：503-517）评估了大肠杆菌基因组的几个部分与代表性肠细菌基因组的相应部分的相关程度。 （1975年）。相关程度在所检查的区域之间有所不同。从高度同源的各种肠基因组中脱氧核糖核酸的相对量以及在这些区域中限制酶切割位点的保守性来看，肠基因组在某些基因组中比在其他部分中差异更大。 。基因组的各个部分（包括tnaA和thyA基因，trp操纵子和另一个未分配的区段）似乎与整个基因组一致进化。相比之下，lacZ基因和与噬菌体λ同源的基因组部分变化范围更大，也许反映了脱氧核糖核酸这些片段的独立进化起源。

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