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首页> 外文期刊>Journal of bacteriology >Sequence divergence in the ORF6 gene of Mycoplasma pneumonia.
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Sequence divergence in the ORF6 gene of Mycoplasma pneumonia.

机译：支原体肺炎的ORF6基因的序列差异。

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摘要

The ORF6 gene product of Mycoplasma pneumoniae is involved in a yet-unknown manner in the adhesion of the bacterium to its host cell. Part of the ORF6 gene is a repetitive DNA sequence (RepMP5), about 1,900 bp long. Seven additional similar copies of RepMP5 are dispersed on the genome. In the independently isolated strains M. pneumoniae M129 and FH, the RepMP5 copies residing in the ORF6 gene are not identical. Two conserved regions, ranging from nucleotides 1 to 799 and from nucleotide 1795 to the end of the gene, border a variable region, ranging from nucleotides 800 to 1794. This variable region differs in DNA sequence and by 201 bp. Analysis of RepMP5 copies outside the ORF6 gene showed that both M. pneumoniae M129 and M. pneumoniae FH carry a RepMP5 copy on a 6-kbp EcoRI fragment which has the same DNA sequence as the variable region of RepMP5 in the M. pneumoniae FH ORF6 gene. According to these data, a switch from the M. pneumoniae M129 ORF6 gene to the M. pneumoniae FH ORF6 gene could take place by gene conversion.
机译：肺炎支原体的ORF6基因产物以一种未知的方式参与了细菌与其宿主细胞的粘附。 ORF6基因的一部分是一个重复的DNA序列（RepMP5），长约1,900 bp。 RepMP5的七个其他类似副本分散在基因组上。在独立分离的肺炎支原体M129和FH菌株中，ORF6基因中的RepMP5拷贝不同。两个保守区，从核苷酸1至799，从核苷酸1795到基因末端，与可变区相邻，从核苷酸800至1794。该可变区的DNA序列相差201 bp。对ORF6基因外部的RepMP5拷贝的分析表明，肺炎支原体M129和肺炎支原体FH均在6 kbp EcoRI片段上带有RepMP5拷贝，该片段具有与肺炎支原体FH ORF6的RepMP5可变区相同的DNA序列。基因。根据这些数据，可以通过基因转换从肺炎支原体M129 ORF6基因切换到肺炎支原体FH ORF6基因。

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