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首页> 外文期刊>Journal of bacteriology >Identification and characterization of uvrA, a DNA repair gene of Deinococcus radiodurans.
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Identification and characterization of uvrA, a DNA repair gene of Deinococcus radiodurans.

机译：uvrA的鉴定和鉴定，uvrA是一种放射性杜鹃球菌的DNA修复基因。

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Deinococcus radiodurans is extraordinarily resistant to DNA damage, because of its unusually efficient DNA repair processes. The mtcA+ and mtcB+ genes of D. radiodurans, both implicated in excision repair, have been cloned and sequenced, showing that they are a single gene, highly homologous to the uvrA+ genes of other bacteria. The Escherichia coli uvrA+ gene was expressed in mtcA and mtcB strains, and it produced a high degree of complementation of the repair defect in these strains, suggesting that the UvrA protein of D. radiodurans is necessary but not sufficient to produce extreme DNA damage resistance. Upstream of the uvrA+ gene are two large open reading frames, both of which are directionally divergent from the uvrA+ gene. Evidence is presented that the proximal of these open reading frames may be irrB+.
机译：由于其异常有效的DNA修复过程，Radiocorancus radiodurans非常耐DNA损伤。都与切除修复相关的D. radiodurans的mtcA +和mtcB +基因已被克隆和测序，表明它们是单个基因，与其他细菌的uvrA +基因高度同源。大肠杆菌uvrA +基因在mtcA和mtcB菌株中表达，并且在这些菌株中产生了高度的修复缺陷互补，这表明放射性杜鹃D. UvrA蛋白是必需的，但不足以产生极端的DNA损伤抗性。 uvrA +基因的上游是两个大的开放阅读框，这两个阅读框都与uvrA +基因有方向性的区别。证据表明这些开放阅读框的近端可能是irrB +。

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