Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.

J S Gunn; E L Hohmann; S I Miller

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Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.

机译：沙门氏菌毒力的转录调控：PhoQ周质结构域突变导致向PhoP的净磷酸转移增加。

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A mutation in the phoP/phoQ locus (pho-24) that results in unregulated expression of PhoP-activated genes (phenotype PhoP constitutive [PhoP(c)]) was mapped to phoQ. Change of a Thr to Ile at position 48 of PhoQ was responsible for the PhoP(c) phenotype (attenuation of mouse virulence, defects in epithelial cell invasion, and macrophage spacious phagosome formation). PhoP phosphorylation by membrane extracts required PhoQ, and PhoQ Ile-48-containing membranes demonstrated increased net phosphorylation of PhoP.

机译：将phoP / phoQ基因座（pho-24）中导致PhoP激活基因（表型PhoP组成型[PhoP（c）]）表达失控的突变定位到phoQ。在PhoQ的第48位，Thr变为Ile引起PhoP（c）表型（小鼠毒力减弱，上皮细胞侵袭缺陷和巨噬细胞宽敞的吞噬体形成）。膜提取物对PhoP的磷酸化需要PhoQ，而含PhoQ Ile-48的膜证明PhoP的净磷酸化增加。

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《Journal of bacteriology》 |1996年第21期|共5页
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J S Gunn; E L Hohmann; S I Miller;
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中图分类微生物学;
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1. In Vivo Genetic Analysis Indicates That PhoP-PhoQ and the Salmonella Pathogenicity Island 2 Type III Secretion System Contribute Independently to Salmonella enterica Serovar Typhimurium Virulence [J] . Carmen R. Beuzón, Kate E. Unsworth, David W. Holden Infection and immunity . 2001,第12期

机译：体内遗传学分析表明PhoP-PhoQ和沙门氏菌致病岛2型III分泌系统独立地贡献于肠杆菌沙门氏菌鼠伤寒沙门氏菌毒力。
2. Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ [J] . Navarre WW, Halsey TA, Walthers D, Molecular Microbiology . 2005,第2期

机译：SlyA和PhoP / PhoQ对毒力和对抗菌肽耐药的沙门氏菌肠基因的共调控
3. Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ [J] . Guo L, Lim KB, Gunn JS, Science . 1997,第5310期

机译：鼠伤寒沙门氏菌毒力基因phoP-phoQ对脂质A修饰的调控
4. MUTATIONAL MAPPING AND LOCATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN SALMONELLA ENTERITIDIS ISOLATES THAT VARY IN VIRULENCE [C] . Jean Guard-Bouidin Annual Meeting of the United States Animal Health Association . 2007

机译：突变映射和单核苷酸多态性在沙门氏菌中的单核苷酸多态性的位置，其分离物在毒力不变
5. Structure-function relationships of periplasmic membrane-derived oligosaccharides in Salmonella growth and virulence. [D] . Jun, Won. 2006

机译：沙门氏菌生长和毒力中周质膜衍生寡糖的结构功能关系。
6. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. [O] . J S Gunn, E L Hohmann, S I Miller 1996

机译：沙门氏菌毒力的转录调控：PhoQ周质结构域突变导致向PhoP的净磷酸转移增加。
7. Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP. [O] . Gunn, J S, Hohmann, E L, Miller, S I 1996

机译：沙门氏菌毒力的转录调控：PhoQ周质结构域突变导致向PhoP的净磷酸转移增加。

Transcriptional regulation of Salmonella virulence: a PhoQ periplasmic domain mutation results in increased net phosphotransfer to PhoP.

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