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首页> 外文期刊>Journal of bacteriology >Overrepresentation of a Gene Family Encoding Extracytoplasmic Solute Receptors in Bordetella
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Overrepresentation of a Gene Family Encoding Extracytoplasmic Solute Receptors in Bordetella

机译:博德特氏菌编码胞质溶质受体的基因家族的过度代表。

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A family of genes that are likely to encode extracytoplasmic solute receptors is strongly overrepresented in several β-proteobacteria, including Bordetella pertussis. This gene family, of which members have been called bug genes, contains some examples that are contained within polycistronic operons coding for tripartite uptake transporters of the TTT family, while the vast majority are “orphan” genes. Proteomic and functional analyses demonstrated that several of these genes are expressed in B. pertussis, and one is involved in citrate uptake. The bug genes probably form an ancient family that has been subjected to a large expansion in a restricted phylogenic group.
机译:一个可能编码胞质溶质受体的基因家族在包括百日咳杆菌(Bordetella pertussis)在内的数种β变形杆菌中均过分表达。这个基因家族的成员被称为 bug 基因,包含一些例子,这些例子包含在多顺反子操纵子中,这些操纵子编码TTT家族的三方摄取转运蛋白,而绝大多数是“孤儿”基因。蛋白质组学和功能分析表明,其中一些基因在B中表达。百日咳,其中一种参与柠檬酸盐的吸收。 bug 基因可能形成一个古老的家族,该家族在有限的系统发育群体中经历了大的扩张。

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